中国药房2013，Vol.24Issue(26)：2427-2429,3.DOI:10.6039/j.issn.1001-0408.2013.26.11
他克莫司血药浓度监测与合理用药分析
Analysis of Blood Concentration Monitoring of Tacrolimus and Rational Use of Drugs
谢华 1王荣 1武晓玉 1李文斌 1张娟红 1贾正平1
作者信息
- 1. 兰州军区兰州总医院全军高原环境损伤防治重点实验室/全军临床药理基地,兰州730050
- 折叠
摘要
Abstract
OBJECTIVE:To provide reference for blood concentration monitoring of tacrolimus (FK506) and clinical use of drug by analyzing the blood concentration monitoring results of FK506 and referring to the effective range of treatment.METHODS:Blood concentration of FK506 in 977 patients as research object was determined by retrospective method in our hospital during Dec.2011-Dec.2012.Therapeutic effect of normal range of blood concentration monitoring was analyzed as well as results of abnormal monitoring.RESULTS:Among 977 patients,blood concentration of FK605 which was equal to,lower than or higher than reference range accounted for 65.5％,33.2％ and 1.3％,respectively.Abnormal blood concentration may be related to the compliance of patient and drug dosage.The adverse drug reactions of FK506 was rarely found.CONCLUSIONS:FK506 should follow the principle of individual medication,starting from small dose; based on the blood concentration of FK506,liver and kidney function and the body's tolerance were evaluated comprehensively to adjust medication timely.关键词
他克莫司/血药浓度监测/合理用药Key words
Tacrolimus/ Blood concentration monitoring/ Rational use of drugs分类
医药卫生引用本文复制引用
谢华,王荣,武晓玉,李文斌,张娟红,贾正平..他克莫司血药浓度监测与合理用药分析[J].中国药房,2013,24(26):2427-2429,3.
