中国药理学通报2013，Vol.29Issue(7)：903-907,5.DOI:10.3969/j.issn.1001-1978.2013.07.005
Wingless/Wnt信号与缺血性脑中风中神经血管单元相关的研究进展
Advances in studies on correlations between Wingless/Wnt signals and the neurovascular unit in ischemic stroke
摘要
Abstract
Wingless ( Writs ) signaling pathway acts as a complex protein interaction network, through autocrine and paracrine to regulate the occurrence and development of a variety of cells, which has biological significance. In recent years, a new model, the neurovascular unit ( NVU ) aimed at the overall protection of nerves and blood vessels, has been put forward, and becomes a hot topic. Wnt signaling pathway may play an important role in neurovascular unit protection of ischemic stroke. Wnts family combining with Frizzled/Low-density Lipoprotein related proteins 5/6 proteins ( LRP5/6 ), which transfer into cells, can activate hypoxia inducible factor-la ( HIF-1α ) after a series of reactions, regulate the vascular endothelial growth factor ( VEGF ) expression at the gene level ( Wnts is as upstream signal of HIF-1α and VEGF ), and then activate the down-stream signal molecules through up-regulating the β-catenin to regulate gene and protein level of the Blood Brain Barrier( BBB ) and NVU as the final result, which promotes the repair after the ischemic stroke injury at the overall level.关键词
Wnt信号通路/神经血管单元(NVU)/BBB/HIF-1α/VEGF/缺血性脑中风Key words
Wnt signaling pathway/ neurovascular unit( NVU )/ BBB/ HIF-1α/ VEGF/ ischemic stroke分类
医药卫生引用本文复制引用
文丽梅,杨洪军,马超英,陈畅,高健,吴传鸿,朱丽,李韶菁..Wingless/Wnt信号与缺血性脑中风中神经血管单元相关的研究进展[J].中国药理学通报,2013,29(7):903-907,5.基金项目
国家自然科学基金资助项目(No 30901976,81274133) （No 30901976,81274133）
国家科技部十二五"重大新药创制"重大专项资助项目(No 2012ZX09103-201-055) （No 2012ZX09103-201-055）
