中国药理学通报2013，Vol.29Issue(7)：927-931,5.DOI:10.3969/j.issn.1001-1978.2013.07.010
SUR1和KCNJ11基因多态性与磺脲类药物继发性失效的相关性研究
Relations of SUR1 and KCNJ11 gene polymorphisms with secondary failure of sulfonylurea in type 2 diabetes
摘要
Abstract
Aim To investigate whether the polymorphisms of exon 16 -3 c/tinSUR1 and E23 K in KCNJ1 are correlated with secondary failure of sulfonylurea in type 2 diabetes mellitus. Methods The association of two SNPs in SUR1 and KCNJ11 was studied by genoty-ping them with ABI SNaPshot Multiplex System in 114 patients with sulfonylurea effective, and 86 patients with secondary failure of sulfonylurea. Results The genotype frequencies distribution of KCNJ11 E23K were found to show no significant differences between SU failure group and SU effective group ( P > 0. 05 ). There were significant differences in the distributive frequency of the SUR1 16-3 c/t polymorphism between SU failure group and SU effective group ( P < 0. 01 ) . The risk allele " t" frequencies in SU failure group were significantly higher than that in SU effective group ( odds ratio = 1. 87 ,95% confidence interval: 1. 23 ~ 2. 85 , P <0. 01 ). Adjustment for age, gender, BMI, fasting C-peptide, triglyceride, cholesterin, high-density lipoprotein cholesterol, low density lipoprotein in cholesterol a logistic regression analysis did not change this association ( odds ratio =2.82, 95% confidence interval: 1.57 -5.07, P < 0.01 ). Conclusion These data demonstrate that the polymorphism of exon 16-3c/t in SUR1 may be associated with secondary failure of sulfonylurea in type 2 diabetes mellitus in Shandong Province.关键词
2型糖尿病/磺脲类药物/基因多态性/SNaPshot技术/SUR1/KCNJ11Key words
type 2 diabetes mellitus/ sulfonylurea/ gene polymorphism/ SNaPshot/ SUR1 / KCNJ11分类
医药卫生引用本文复制引用
邵倩,班博,施锦绣..SUR1和KCNJ11基因多态性与磺脲类药物继发性失效的相关性研究[J].中国药理学通报,2013,29(7):927-931,5.基金项目
国家自然科学青年基金资助项目(No 30900828) （No 30900828）
