中国肿瘤生物治疗杂志2013，Vol.20Issue(3)：323-329,7.DOI:10.3872/j.issn.1007-385X.2013.03.012
UbcH10在脑膜瘤组织中的表达及其临床意义
Expression of ubiquitin-conjugating enzyme H10 in meningioma tissues and its clinical significance
摘要
Abstract
Objective:To investigate the expression of ubiquitin-conjugating enzyme H10 (UbcH10) protein in meningiomas tissues of different pathological grades and its clinical significance.Methods:Forty-seven patients diagnosed as meningioma with integrity clinical and follow-up information during April 2002 to September 2009 were selected from Department of Neurosurgery,Changzheng Hospital and were graded according to the 2007 WHO standard.The expressions of UbcH10 and Ki-67 proteins in meningioma tissues of various pathological grades were examined by immunohistochemistry.The correlation between the expressions of UbcH10 and Ki-67 protein was analyzed by using Spearman method.The correlation of UbcH10 expression with meningioma recurrence-free surivival was analyzed using the Kaplan-Meier method.Results:UbcH10 protein was mainly expressed in the cytoplasm of meningioma cells.The expression of UbcH10 protein in meningioma tissues was significantly higher than that in normal brain tissues ([5.57 ± 1.72] ％ vs 0,P =0.00).Quantitative analysis confirmed that the expression of UbcH10 protein was significantly higher in atypical and anaplastic meningiomas as compared with classic meningiomas ([10.53 ± 5.79] ％ vs [4.23 ± 2.85] ％,P ＜ 0.01),indicating that the expression of UbcH10 protein was correlated with meningioma pathological grade and recurrence.The expression of UbcH10 protein was correlated with the expression of Ki-67 protein (r =0.77,P ＜ 0.01).Kaplan-Meier survival curve result indicated patients with high expression level of UbcH10 and Ki-67 and higher pathological grade showed a significantly shortened recurrence-free surivival than those with a lower expression level of UbcH10 (P =0.007) and Ki-67 (P =0.018),and a lower pathological grade (P ＜ 0.01).Cox multivariate regression analysis showed that the pathological grade (P =0.029) and the expression level of UbcH10 (P =0.044) were independent prognosis factors for meningioma patients,with the hazard ratio of 2.918 and 4.756,respectively.Whereas,the clinicopathological factors,including age,gender,Ki-67 level,tumor diameter and tumor location were not independent factors for prognosis.Conclusion:UbcH10 may be involved in the development and progression of meningioma,and UbcH10 expression is an independent risk factor that could predict the prognosis.关键词
脑膜瘤/UbcH10/Ki-67/预后/生存分析Key words
meningioma/ ubiquitin-conjugating enzyme H10 (UbcH10)/Ki-67/prognosis/ survival analysis分类
医药卫生引用本文复制引用
王涛,王国喜,鲁维山,顾伏平,王奇章,卢亦成,胡国汉..UbcH10在脑膜瘤组织中的表达及其临床意义[J].中国肿瘤生物治疗杂志,2013,20(3):323-329,7.基金项目
上海市科学技术委员会基金资助项目(No.08431900400). Project supported by the Scientific Foundation of Science and Techology Committee of Shanghai(No.08431900400) （No.08431900400）
