中华临床免疫和变态反应杂志2013，Vol.7Issue(2)：109-114,6.
系统性红斑狼疮患者外周血干扰素α、白介素6和肿瘤坏死因子α水平
Levels of Interferon α、Interlenkin 6 and Tumor Necrosis Factor α in Serum of Patients with Systemic Lupus Erythematosus
摘要
Abstract
Objective To detect the serum levels of interferon α ( IFN-α) , interlenkin 6 ( IL-6 ) and tumor necrosis factor α (TNF-α) and explore the pathogenesis of cytokines in systemic lupus erythematosus (SLE). Methods The serum levels of IFN-α, IL-6 and TNF-α were measured by ELISA assay in SLE patients and normal controls. The correlations between laboratory parameters and clinical manifestations were evaluated. Results The serum levels of IFN-α, IL-6 in patients with SLE were significantly higher as compared with those in normal controls [ (4. 99 ± 7. 47 ) ng/L vs. ( 2. 07 ± 1. 98 ) ng/L, ( 4. 36 ± 7. 62 ) ng/L vs. (1.72 ±2. 87) ng/L, both P < 0. 05]. The level of IFN-a in patients with active disease was significantly higher than that in patients with inactive disease [ ( 9. 79 ± 12. 04 ) ng/L vs. (3.13 ±3. 47 ) ng/L, P < 0. 05 ]. The serum IFN-α level in patients with anemia was significantly elevated compared to those with normal hemoglobin [ (5. 34 ± 6. 36 ) ng/L vs. ( 2. 84 ± 3. 58 ) ng/L, P < 0. 05 ]. Patients with positive anti-dsDNA antibody had significantly higher serum levels of IFN-α and IL-6 than those with negative anti-dsDNA antibody [(7. 35 ±8. 12) ng/L vs. (4.22±8.11) ng/L, (10. 26 ±12. 76) ng/L vs. (2. 37 ± 1. 61 ) ng/L, both P < 0. 05 ]. The serum level of IFN-α in SLE was positively correlated with TNF-α, SLEDAI score and anti-dsDNA antibody ( r = 0. 303 , P < 0. 05 ; r = 0. 427 , P < 0. 01; r = 0. 368 , P <0. 05) , and negatively correlated with hemoglobin (r = -0. 345, P < 0. 05 ). The serum level of IL-6 was positively correlated with ESR and anti-dsDNA antibody (r =0. 526, P <0. 01; r =0. 437, P <0. 05). The serum level of IFN-α was significantly increased in patients with hematological system involvement (P < 0. 05) , and the level of IL-6 was significantly increased in patients with fever, arthritis and hematological system involvement in comparison with the patients without these manifestations ( P < 0. 01 or P < 0. 05 ) . Conclusion The cytokines in peripheral blood of SLE are abnormally secreted, which may interact with each other and participate in the onset and progression of the disease.关键词
红斑狼疮,系统性/干扰素α/白介素6/肿瘤坏死因子αKey words
lupus erythematosus, systemic/ interferon α/ interleukin 6/ tumor necrosis factor α分类
医药卫生引用本文复制引用
周晶晶,汪国生,李向培,厉小梅,钱龙..系统性红斑狼疮患者外周血干扰素α、白介素6和肿瘤坏死因子α水平[J].中华临床免疫和变态反应杂志,2013,7(2):109-114,6.基金项目
国家自然科学基金(81072462),安徽省高校省级自然科学研究项目(KJ2010A188) （81072462）
