中华临床免疫和变态反应杂志2013，Vol.7Issue(2)：115-119,5.
血清葡萄糖6-磷酸异构酶抗原、类风湿因子和第2代抗环瓜氨酸肽抗体对类风湿关节炎诊断价值的比较
Comparison of Diagnostic Values of Serum Glucose-6-Phosphate Isomerase, Rheumatoid Factor, and Second-generation Anti-cyclic Citrullinated Peptide Antibodies Assays for Rheumatoid Arthritis
吴庆军 1唐福林 1潘童 2邓垂文 1胡朝军 1朱安礼 3潘峥 4史艳萍 1李永哲 1曾小峰1
作者信息
- 1. 中国医学科学院,北京协和医学院,北京协和医院风湿免疫科,北京,100032
- 2. 山东省临清市聊城第二人民医院风湿科,临清,252600
- 3. 山东省临清市聊城第二人民医院骨科,临清,252600
- 4. 北京市西苑医院风湿科,北京,100091
- 折叠
摘要
Abstract
Objective To assess the diagnostic value of serum glucose-6-phosphate isomerase (GPI) antigen in rheumatoid arthritis( RA) , and compared with rheumatoid factor (RF) and the second generation of anti-cyclic citrullinated peptide (CCP2) antibody. Methods Samples from 126 RA cases and 122 non-RA disease cases were tested. GPI and anti-CCP2 antibodies were detected by enzyme linked immunosorbent assay. Results The mean level of GPI was significantly higher in RA patients than that in non-RA group [ (0. 28 ±0. 65) mg/L vs (0. 07 ±0. 36) mg/L, P <0. 005]. GPI was significantly less sensitive than RF (32. 5% vs 69. 0% , P <0. 001) and anti-CCP2 autoantibody (32. 5% vs 72. 2% , P <0. 001) for RA. The specificity of GPI, RF and anti-CCP2 antibody for RA was 89. 3% , 87. 7% and 95. 1% respectively. Compared with anti-CCP2 antibody, the combination assays of GPI, RF; GPI, anti-CCP2 and GPI + RF + anti-CCP2 showed significantly lower diagnostic sensitivity (P < 0. 001 ) ; combination assays of GPI/RF, GPI/anti-CCP2 and GPI/RF/anti-CCP2 antibody demonstrated significantly lower diagnostic specificity (P < 0. 05 ). Conclusions GPI is less sensitive for RA, and anti-CCP2 antibody has been demonstrated to have very good sensitivity and high specificity.关键词
葡萄糖6-磷酸异构酶/第2代抗环瓜氨酸肽抗体/类风湿关节炎Key words
glucose-6-phosphate isomerase/ anti-CCP2 antibody/ rheumatoid arthritis分类
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吴庆军,唐福林,潘童,邓垂文,胡朝军,朱安礼,潘峥,史艳萍,李永哲,曾小峰..血清葡萄糖6-磷酸异构酶抗原、类风湿因子和第2代抗环瓜氨酸肽抗体对类风湿关节炎诊断价值的比较[J].中华临床免疫和变态反应杂志,2013,7(2):115-119,5.
