中华临床免疫和变态反应杂志2013，Vol.7Issue(2)：160-166,7.
淋巴免疫治疗过敏性哮喘的临床疗效
Clinical Efficacy of Intralymphatic Immunotherapy for Allergic Asthma
雍磊 1高春芳 1程相铎 1王俊琦 1李华信 1董学文 1贾丹 1张彩霞 1何静1
作者信息
- 1. 中国人民解放军第150中心医院变态反应中心,河南洛阳,471031
- 折叠
摘要
Abstract
Objective To evaluate the clinical efficacy and safety of intralymphatic immunotherapy with standardized Dermatophagoides pteronyssinus allergen vaccine for Dermatophagoides pteronyssinus-induced allergic asthma. Methods 72 patients with Dermatophagoides pteronyssinus -induced allergic asthma were randomly divided into intralymphatic immunotherapy treatment group and control group, 36 cases were enrolled in each group. Patients in control group were prescribed budesonide and salbutamol aerosol while patients in intralymphatic immunotherapy treatment group were prescribed above medications and also received 6 ultrasound-guided intra-superficial lymph node injections by using standardized aluminum-adsorbed Dermatophagoides pteronyssinus allergen vaccine ( Alutard ALK, Denmark) every four weeks. The evaluation of clinical efficacy was based on serum Dermatophagoides pteronyssinus slgE, asthma control test (ACT) , pulmonary function test [FEV1% , FEV1/FVC and PEF% ] , medication score on baseline and after treatment, comparing with control group. Adverse reactions were also recorded. Results 32 cases in treatment group completed the study, 2 cases dropped out due to pregnancy and another 2 cases lost. 32 cases in control group completed the study and 4 cases lost. ACT scores, FEV1% , FEV1/FVC sand PEF % values of patients' in intralymphatic immunotherapy group increased significantly, comparing with that of patients in control group. Medication scores and serum Dermatophagoides pteronyssinus slgE of patients in treatment group decreased significantly, comparing with that of pre-treatment and that of in control group. There was no local and systemic adverse reaction in 192 intralymphatic injections among 32 patients. Conclusions Allergen specific ntralymphatic immunotherapy is not only very effective, but also can remarkably shorten the duration of immunotherapy, reduce the number and dose of injection and decrease adverse reaction. Intralymphatic immunotherapy with standardized Dermatophagoides pteronyssinus allergen vaccine is an effective and safe causative treatment for Dermatophagoides pteronyssinus allergic asthma.关键词
标准化变应原/屋尘螨/过敏性哮喘/淋巴免疫治疗Key words
standardized allergen/ dermatophagoides pteronyssinus/ allergic asthma/ intralymphatic immunotherapy分类
医药卫生引用本文复制引用
雍磊,高春芳,程相铎,王俊琦,李华信,董学文,贾丹,张彩霞,何静..淋巴免疫治疗过敏性哮喘的临床疗效[J].中华临床免疫和变态反应杂志,2013,7(2):160-166,7.
