肿瘤防治研究2013，Vol.40Issue(6)：541-546,6.DOI:10.3971/j.issn.1000-8578.2013.06.009
HIA与IA方案治疗初治急性髓系白血病的临床对比观察
Clinical Comparative Observation of HIA and IA Regimen in Initial Treatment of Newly Diagnosed Acute Myeloid Leukemia
张曦 1常春康 1赵佑山 1郭娟 1费诚明 1李晓1
作者信息
- 1. 200233上海,上海交通大学附属第六人民医院血液科
- 折叠
摘要
Abstract
Objective Newly diagnosed acute myeloid leukemia patients were initially treated with conventional IA regimen and dual induction chemotherapy of HIA consisting of idamycin (IDA) regimen and HA [homoharringtonine (HH) + cytosine arabinoside] regimen.Therapeutic effects and adverse effects of two regimens also were studied.Methods Forty-three patients were recruited into the HIA group (IDA 7 mg/(m2·d),Day 1-3; HH 2.5 mg/(m2·d),Day 1-5; Ara-C 100 mg/(m2·d),Day 1-5) and30 patients into the IA group(IDA 10 mg/(m2 ·d),Day 1-3; Ara-C 100 mg/(m2 ·d),Day 1-5).Results Complete remission (CR) rate was 74.4％ (32/43) in HIA group and 73.3％ (26/30) in IA group in the first course.9 patients relapsed during follow-up (1 early relapse and 8 late relapses)in patients achieved CR of HIA group,and 8 patients relapsed (5 early relapse and 3 late relapses) in IA group.No significant differences were observed between the two groups in terms of CR rate and survival.However,the incidence of heart adverse effects was significantly lower in HIA group (2.3％) than that in the IA group (16.7％).The adverse effects in HIA regimen were mainly infections resulted from bone marrow depression (BMD) and no serious non-hematopoietic system adverse effects and particularly aggravate cardiotoxicity were observed.No early death happened during the treatment course.Conclusion HIA regimen had acceptable effects and not aggravating cardiotoxicity although the dosage of anthracyclines was decreased.关键词
急性髓系白血病/去甲氧柔红霉素/高三尖杉酯碱/阿糖胞苷Key words
Acute myeloid leukemia(AML) / Idamycin(IDA) / Homoharringtonine(HH) / Cytosine arabinoside(Ara-c)分类
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张曦,常春康,赵佑山,郭娟,费诚明,李晓..HIA与IA方案治疗初治急性髓系白血病的临床对比观察[J].肿瘤防治研究,2013,40(6):541-546,6.
