肿瘤防治研究2013，Vol.40Issue(6)：572-575,4.DOI:10.3971/j.issn.1000-8578.2013.06.016
瘦素、雌激素及雌激素受体在肺癌组织中的表达及其相关性
Relationship and Expression of Leptin, Estrogen and Estrogen Receptor in Lung Cancer Tissue
摘要
Abstract
Objective To study the expressions of Leptin,Estrogen and Estrogen receptor(ER) in lung adenocarcinoma and squamous cell carcinoma.Methods The expressions of Leptin,Estrogen and Estrogen receptor were detected in 41 cases of lung adenocarcinoma and 32 cases of squamous cell carcinoma tissues by immunohistochemistry.Results In 41 cases of lung adenocarcinoma,the expression rates of Leptin,Estrogen and Estrogen receptor(ER) were 78.05％ (32/41),36.59％ (15/41) and 60.98％ (25/41),respectively,and higher than those in 32 lung squamous cell carcinoma 56.25 ％ (18/32),15.63 ％ (5/32) and 37.5％ (12/32),respectively (P＜0.05).In 27 female cases with adenocarcinoma,the expression rate of ER was increased,compared 14 male cases with adenocarcinoma,74.07％ (20/27) vs.35.71％(5/14) (P＜0.05).However,the expressions of Leptin,Estrogen had no relations to gender,histology types,clinical stage (P＞0.05).Conclusion Leptin,Estrogen and ER were highly expressed in lung adenocarcinoma.ER was highly expressed in female adenocarcinoma.The expressions of Leptin,Estrogen and Estrogen receptor(ER) may associated with the carcinogenesis and development of lung adenocarcinoma.关键词
瘦素/雌激素/雌激素受体/肺腺癌Key words
Leptin/ Estrogen/ Estrogen receptor/ Adenocarcinoma of lung分类
医药卫生引用本文复制引用
杨成喜,张蕾,吴风雷,冯文..瘦素、雌激素及雌激素受体在肺癌组织中的表达及其相关性[J].肿瘤防治研究,2013,40(6):572-575,4.基金项目
连云港市卫生局2010年科研项目资助课题(1103) （1103）
