中医药学报2013，Vol.41Issue(3)：59-63,5.
芎麻滴丸中阿魏酸及天麻素的体内药动学研究
Pharmacokinetic Study of Ferulic Acid and Gastrodin in Xiongma Drip Pills
摘要
Abstract
Objective:The pharmacokinetics and concentration-time curve of Xiongma Drip Pills were study to improve the basic research.Method:The contents of ferulic acid and gastrodin in Xiongma Drip Pills were determinated by HPLC.16 SD rats were randomly divided into two groups.Low doses of XiongMa Drip Pills were given to (3g crude drugs kg-1) and high dose (6g crude drug kg-1) solution.Protein in rat plasma samples was precipitated by methanol.Peak area was recorded,and the plasma concentration was calculated.The 3P97 analysis was used to deal with ferulic acid and gastrodin,pharmacokinetic parameters.Results:AUC was strongly positive linear dose-related with dose.Xiongma Drip Pills in rats rendered as a dynamic behavior.T1/2 Ka of ferulic acid was 5min,while t1/2 Ke was 28min.T1/2 Ka of gastrodin was 21min,while t1/2 Ke was 114 min.Conclusion:3g/kg ～6g/kg Xiongma Drip Pills have a rapid effect in people's bodies and have a short half-life.关键词
芎麻滴丸/阿魏酸/天麻素/药动学Key words
Xiongma Drip Pills / Ferulic acid / Gastrodin/ Pharmacokinetics分类
医药卫生引用本文复制引用
刘琳,王立,赵瑛,张颖,李传钰,宋诚挚,谭颖,孙忠人..芎麻滴丸中阿魏酸及天麻素的体内药动学研究[J].中医药学报,2013,41(3):59-63,5.基金项目
黑龙江省中药管理局项目(2010) （2010）
黑龙江省教育厅项目(12521140) （12521140）
黑龙江省教育厅项目(12511134) （12511134）
