高等学校化学学报2013，Vol.34Issue(7)：1646-1652,7.DOI:10.7503/cjcu20121077
5-苄基4-叔丁基-2-芳氨基噻唑氢溴酸盐的合成、表征及抗肿瘤活性
Synthesis, Characterization and Antitumor Activities of 5-Benzyl-4-tert-butyl-N-arylthiazol-2-amine Hydrobromide
摘要
Abstract
Recently,more and more thiazole compounds were reported to exhibit antitumor activities.Twentynine new 5-benzyl-4-tert-butyl-N-arylthiazol-2-amine hydrobromides were synthesized from arylamino and 2-bromo-4,4-dimethyl-1-arylpentan-3-one.Their structures were confirmed by 1H NMR spectra and elemental analysis.The data of antitomor activities in vitro indicated that the IC50 values of compounds A4,A5,A12and A29 against A549 cells were 0.016,0.019,0.019 and 0.026 μmol/mL,respectively,similar to Taxinol (IC50 value was 0.022 μmol/mL).The IC50 values of compounds A5,A7,A13,A14 and A19 against Bel7402 were 0.021,O.021,0.026,0.014 and 0.029 μmol/mL,respectively,similar to Taxinol(IC50 value was 0.030 μmol/mL).The shape changes of A549 cells were observed by inverted microscope and flourescence microscope after staining with Hoechst 33342-PI.关键词
5-苄基-4-叔丁基-2-芳氨基噻唑/合成/抗肿瘤活性Key words
5-Benzyl-4-tert-butyl-N-arylthiazol-2-amine hydrobromide / Synthesis / Antitumor activity分类
化学化工引用本文复制引用
彭俊梅,李婉,申坤,霍素芳,叶姣,胡艾希..5-苄基4-叔丁基-2-芳氨基噻唑氢溴酸盐的合成、表征及抗肿瘤活性[J].高等学校化学学报,2013,34(7):1646-1652,7.基金项目
湖南省自然基金重点项目(批准号:07JJ3022)资助. （批准号:07JJ3022）
