国际医药卫生导报2013，Vol.19Issue(14)：2180-2183,4.DOI:10.3760/cma.j.issn.1007-1245.2013.14.041
高血压病患者血浆生长分化因子-15水平与左心室几何构型的关系
Relationship between plasma GDF-15 and left ventricular geometry in essential hypertension
李宁 1曾哲彤 1何芸 2赵晶晶1
作者信息
- 1. 510120 广州医学院第一附属医院检验科
- 2. 510220 广州市红十字会医院/暨南大学医学院第四附属医院
- 折叠
摘要
Abstract
Objective To investigate the relationship between the levels of plasma growth-differentiation factor-15 (GDF-15) and left ventricular geometry in patients with essential hypertension.Methods 61 essential hypertension patients who achieved successful blood pressure control were studied with echocardiographic examination.According to left ventricular mass index (LVMI) and relative wall thickness (RWT),patients were divided into left ventricular normal geometry group (n=13),concentric remodeling group (n=15),concentric hypertrophy group (n=18) and eccentric hypertrophy group (n=15).20 healthy subjects were enrolled as control.The levels of plasma GDF-15 were measured with enzyme linked immunosorbent assay (ELISA).Results There was no significant difference in the level of plasma GDF-15 between the control group and the normal geometry group [(228.69 ± 113.45) vs.(233.32 ± 87.62) ng/L,P＞0.05].Compared with the control group,the plasma GDF-15 levels were higher in the concentric remodeling group [(310.81 ± 95.48) vs.(228.69 ± 113.45) ng/L,P＜0.05],concentric hypertrophy group [(379.66 ± 114.57) vs.(228.69 ± 113.45) ng/L,P＜0.01[and eccentric hypertrophy group [(474.80 ± 85.14) vs.(228.69 ± 113.45) ng/L,P＜0.01].The level of plasma GDF-15 in the concentric remodeling group was higher than that in the normal geometry group [(310.81 ± 95.48) vs.(233.32 ± 87.62) ng/L,P=0.048],but was similar with that in the concentric hypertrophy group [(310.81 ± 95.48) vs.(379.66 ± 114.57),P=0.057].The level of plasma GDF-15 in the eccentric hypertrophy group was higher than that in the concentric hypertrophy group [(474.80 ± 85.14) vs.(379.66 ± 114.57) ng/L,P=0.009].There was significant positive correlation between the levels of plasma GDF-15 and LVMI (P＜0.05) in patients with ventricular hypertrophy.Conclusion Left ventricular hypertrophy level can be best assessed by plasma GDF-15 levels even in essential hypertension patients who achieve successful blood pressure control.关键词
高血压病/生长分化因子/左心室肥厚Key words
Essential hypertension/Growth-differentiation factor/Left ventricular hypertrophy引用本文复制引用
李宁,曾哲彤,何芸,赵晶晶..高血压病患者血浆生长分化因子-15水平与左心室几何构型的关系[J].国际医药卫生导报,2013,19(14):2180-2183,4.
