同济大学学报（医学版）2013，Vol.34Issue(3)：17-19,23,4.DOI:10.3969/j.issn1008-0392.2013.03.004
骨保护素基因启动子单核苷酸多态性与脊髓型颈椎病的相关研究
Association of osteoprotegerin gene single nucleotide polymorphisms with cervical spondylotic myelopathy in Chinese subjects
徐广辉 1满毅 1张咏 1康健 2刘永 2贾连顺2
作者信息
- 1. 第二军医大学附属长征医院闸北分院骨科,上海200070
- 2. 第二军医大学附属长征医院骨科,上海200003
- 折叠
摘要
Abstract
Objective To investigate the association between osteoprotegerin gene single nucleotide polymorphisms (SNPs) and cervical spondylotic myelopathy (CSM) in Chinese subjects.Methods DNA were extracted from peripheral blood samples of 192 patients with CSM and 192 matched healthy subjects.The SNP genotype and allele frequency distribution of osteoprotegerin gene promoter 149 and 192 were detected with PCR and restriction endonuclease techniques.JOA scores were used to assess the severity of CSM,and cervical MRI was used to reveal the numbers of segments involved.The association between osteoprotegerin gene SNPs and CSM was analyzed with x2-test.Results There were significant differences in genotype distribution of 149 T/C between two groups,no significant differences in 950 T/C.There was no difference in JOA scores and segments involved in different genotypes of 149 T/C.Logistic analysis showed that 149 SNP and mean desk work time were independent risk factors for CSM.Conclusion The 149 SNPs of osteoprotegerin gene might be a genetic risk factor for cervical spondylotic myelopathy,but not for the severity of the disease.关键词
基因/单核苷酸多态性/骨保护素/脊髓型颈椎病Key words
gene/ single nucleotide polymorphism/ osteoprotegerin/ cervical spondylotic myelopath分类
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徐广辉,满毅,张咏,康健,刘永,贾连顺..骨保护素基因启动子单核苷酸多态性与脊髓型颈椎病的相关研究[J].同济大学学报（医学版）,2013,34(3):17-19,23,4.
