同济大学学报（医学版）2013，Vol.34Issue(3)：53-56,4.DOI:10.3969/j.issn1008-0392.2013.03.013
炎症性肠病患者血清促吞噬素水平及临床意义
Serum tuftsin levels in inflammatory bowel diseases and its clinical significance
摘要
Abstract
Objective To investigate serum tuftsin levels in patients with inflammatory bowel diseases (IBD) and its clinical significance.Methods Serum Tuftsin levels in 24 patients with ulcerative colitis (UC),28 patients with Crohn's disease (CD) and 10 healthy controls were detected by reverse phase high-performance liquid chromatography (RP-HPLC).The correlation between serum Tuftsin level and clinical features was analyzed.Results Compared to the healthy controls,the serum tuftsin levels in CD and UC patients were significantly higher (1.56 ± 1.06) μg/ml,(1.50 ± 1.04) μg/ml vs (0.92 ± 0.58) μg/ml,(P ＜ 0.05).The serum level of Tuftsin was positively correlated with disease activity index and serum C-reactive protein (CRP) elevation (P ＜ 0.05),but was not correlated with the disease locations (P ＞ 0.05).Conclusion The increased serum level of tuftsin and positive correlation with clinical features in patients with IBD suggest that tuftsin may be involved in the pathogenesis of the disease.关键词
促吞噬素/炎症性肠病/克罗恩病/溃疡性结肠炎Key words
Tuftsin/inflammatory bowel disease/Crohn's disease /ulcerative colitis分类
医药卫生引用本文复制引用
陈迟,刘菲..炎症性肠病患者血清促吞噬素水平及临床意义[J].同济大学学报（医学版）,2013,34(3):53-56,4.基金项目
上海市卫生局中医药科研基金(2010L090A) （2010L090A）
