中国临床药理学与治疗学2013，Vol.18Issue(5)：490-494,5.
盐酸表柔比星联合奥沙利铂对肝癌HepG2细胞凋亡的抑制作用
Inhibitory effect of epirubcin hydrochloride co-treated with oxaliplatin in the apoptosis of HepG2 cells
摘要
Abstract
AIM:To investigate the inhibitory effect of epirubcin hydrochloride in combination use with oxaliplatin (L-OHP) on the hepatocellular carcinoma cells HepG2.METHODS:The inhibitory effect of epirubicin hydrochloride together with L-OHP on the growth of human hepatic carcinoma cell line HepG2 in vitro was evaluated by MTT assay.The apoptosis of nucleus was detected by Hoechst33258 staining.The degradation of DNA was evaluated by DNA ladder.RESULTS:Oxaliplatin and epirubicin hydrochloride both inhibited the proliferation of HepG2 cells,it presented addictive inhibition effect when two medicine combined (q value was in 0.85-1.15).CONCLUSION:Oxaliplatin and epirubicin hydrochloride both inhibited the proliferation of HepG2 cells and promoted apoptosis,combination of these medicine presented addictive inhibition effect,however,the mechanism was unclear.关键词
肝癌/奥沙利铂/盐酸表柔比星/细胞凋亡Key words
Hepatocellular carcinoma/ Oxaliplatin/ Epirubicin hydrochloride/ Apoptosis分类
医药卫生引用本文复制引用
王宁,张阳德,廖明媚,赵劲风,陈伟..盐酸表柔比星联合奥沙利铂对肝癌HepG2细胞凋亡的抑制作用[J].中国临床药理学与治疗学,2013,18(5):490-494,5.基金项目
中南大学中央高校基本科研业务资助(2011QZT206) （2011QZT206）
