中国临床药理学与治疗学2013，Vol.18Issue(5)：550-554,5.
ACE基因I/D多态性与风湿性心脏病的相关性研究
Association of angiotensin I-converting enzyme gene insertion/deletion polymorphism with susceptibility of Rheumatic Heart Disease
摘要
Abstract
AIM:To investigate the relationship between angiotensin Ⅰ-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and rheumatic Heart disease (RHD) in Chinese patients.METHODS:Case-control study and polymerase chain reaction (PCR) were used to investigate the ACE I/D polymorphism in 246 patients with RHD and 223 normal people.Patients were further classified into those with only mitral valve lesion or combined valve lesion.Then,the relationship between ACE gene polymorphisms and susceptibility to RHD was studied.RESULTS:No significant difference was observed between the cases and control group.However,the frequency rate of Ⅰ allele in the patients group was higher than that of the controls (70.1％ vs 63.9％),showed a significant difference in the distribution of the ACE Ⅰ allele frequencies (P＜0.05).In the combined valve lesion group,the genotype frequencies of ACE genotypes I/I,I/D and D/D were 51.8％,39.2％ and 9.0％ respectively.ACE Ⅰ allele and D allele frequencies were 71.4％ and 28.6％ respectively.Both the ACE-Ⅱ genotype and the ACE Ⅰ allele frequencies were higher in RHD group (P＜0.05).CONCLUSION:The study shows that ACE I/D gene polymorphisms is associated with development of RHD in Chinese,and ACE Ⅰ allele may be a risk factor for RHD inChinese.关键词
风湿性心脏病/ACE基因/基因多态性/易感性Key words
Rheumatic Heart disease/ ACE gene polymorphism/ Gene polymorphism/ Susceptibility分类
医药卫生引用本文复制引用
张涛,郭成贤,温纯洁,周宏灏..ACE基因I/D多态性与风湿性心脏病的相关性研究[J].中国临床药理学与治疗学,2013,18(5):550-554,5.基金项目
国家自然科学基金项目(81102511) （81102511）
