中国临床药理学与治疗学2013，Vol.18Issue(5)：555-560,6.
RRM1和ERCC1基因外周血中表达水平与吉西他滨联合铂类治疗晚期非小细胞肺癌疗效的相关性研究
RRM1 and ERCC1 expressions and their relationship with gemcitabine and platinum in advanced non-small cell lung cancer
徐浩锋 1王临润 2黄黎 3吕燊3
作者信息
- 1. 浙江省富阳市人民医院,富阳311400,浙江
- 2. 浙江大学医学院附属第一医院,杭州310003,浙江
- 3. 浙江康恩贝制药股份有限公司,杭州310052,浙江
- 折叠
摘要
Abstract
AIM:To evaluate the predictive value of gene expression of ribonucleotide reductase M1 (RRM1) and excision repair cross-complementation 1 (ERCC1) in peripheral blood from Chinese patients with non-small-cell lung cancer (NSCLC) treated with gemcitabine plus platinum.METHODS:SYBR real-time PCR was used to determine the tumor tissue and peripheral blood RRM1 and ERCC1 mRNA expression levels in NSCLC patients.The x2 test was used to analyze categorical variables and Spearman rank correlation analysis was used to analyze continuous variables.Kaplan-Meier survival curves and the log-rank test were used for the comparison of overall survival rates.RESULTS:In the present study,34 Chinese patients with histologically confirmed stages ⅢB and Ⅳ NSCLC were recruited; the tumor tissue and peripheral blood gene expression levels were measured in 22 patients.Linear correlations were observed between peripheral blood and tumor tissue expression levels for RRM1 (R2 =0.045,P=0.048),while no correlation was detected for ERCC1 (R2=0.016,P=0.251).Subjects with low peripheral blood RRM1 expression survived longer than those with high RRM1 expression (16.0 vs 12.5 months,log-rank 3.980,P =0.046).The expression of ERCC1 showed no obvious differences between the two groups.CONCLUSION:The study demonstrates increased survival and superior efficacy of gemcitabine and cisplatin combination chemotherapy in the treatment of NSCLC patients with low peripheral blood RRM1 expression.The results contribute to the selection of patients who are most suitable for treatment with gemcitabine and cisplatin combination chemotherapy.关键词
非小细胞肺癌/吉西他滨/RRM1/ERCC1Key words
Non-small cell lung/ Gemcitabine/ RRM1 /ERCC1分类
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徐浩锋,王临润,黄黎,吕燊..RRM1和ERCC1基因外周血中表达水平与吉西他滨联合铂类治疗晚期非小细胞肺癌疗效的相关性研究[J].中国临床药理学与治疗学,2013,18(5):555-560,6.
