动物营养学报2013，Vol.25Issue(7)：1453-1458,6.DOI:10.3969/j.issn.1006-267x.2013.07.008
鸟氨酸脱羧酶抗酶1基因的结构和功能
Ornithine Decarboxylase Antizyme 1: Molecular Characterization and Functions
摘要
Abstract
The synthesis of ornithine decarboxylase antizyme 1 (OAZ1) protein is mediated by a mechanism involving a programmed + 1 frameshifting during translation of the OAZ1 full-length mRNA.The studies suggest that OAZ1 could bind to ornithine decarboxylase (ODC) and facilitate its degradation,resulting in decreasing the polyamine level in cells; OAZ1 also could bind to cell cycle regulatory proteins including Cyclin D1,Cyclin E1 and Smad1,and then result in blocking the cell cycle.Furthermore,recent studies showed that OAZ1 acted as a tumor suppressor and played an important role in regulating the process of animal reproduction.Furthermore,antizyme inhibitor has a higher affinity for OAZ1 than for ODC,and as such can displace ODC from the ODC-OAZ1 complex and prevent ODC from being degraded.Asparagine can effectively inhibit OAZ1 expression and regulate the ODC activity.In this paper,the research progress in molecular characterization and functions of OAZ1 were reviewed.关键词
鸟氨酸脱羧酶抗酶1/多胺/细胞周期/肿瘤/繁殖Key words
ornithine decarboxylase antizyme 1/ polyamine/ cell cycle/ tumor/ reproduction分类
农业科技引用本文复制引用
马容,康波,姜冬梅,何珲..鸟氨酸脱羧酶抗酶1基因的结构和功能[J].动物营养学报,2013,25(7):1453-1458,6.基金项目
国家自然科学基金资助项目(31201798) （31201798）
高等学校博士学科点专项科研基金项目资助(20105103120003) （20105103120003）
