昆明医科大学学报2013，Vol.34Issue(4)：122-124,3.
内分泌治疗在89SrCl2治疗前列腺癌骨转移中的作用
The Effect of Endocrine Therapy Combined with Strontium-89 of Bone Metastases in Treatment of Patients with Prostate Cancer
刘鹏杰 1唐铭 2马世兴 1朱家伦 1刘超 1王永斌1
作者信息
- 1. 昆明医科大学第三附属医院暨云南省肿瘤医院核医学科,云南昆明 650118
- 2. 昆明理工大学附属医院暨云南省第一人民医院病理科,云南昆明 650032
- 折叠
摘要
Abstract
Objective To analyse the therapeutic effect of strontium-89combined with endocrine therapy of bone metastases in treatment of patients with prostate cancer.Methods 127 prostate cancer patients with bone metastasis who got castrate operation only and felt pain due to bone metastasis from Jan 2009 to Dec 2010 were divided into 3 groups.70 patients of them was in A group and got strontium-89-chloride and medical castration,35 patients of them was in B group and got strontium-89-chloride therapy only and 22 patients of them was in C group and got medical castration only.The VAS score,the ECT bone scanning and the PSA before and 3 months after treatment were compared among three group.Results Before therapy,the VAS scores of A,B,C groups had no statistically significant difference (P ＞ 0.05).After therapy,the pain in patients in A and B groups was significantly alleviated (P ＜ 0.05) but in C group was not significantly alleviated (P ＞ 0.05).There was no statistically significant difference in VAS scores between A and B groups after therapy (P ＞ 0.05),while there was a statistically significant difference between A and C group or B and C group (P ＜ 0.05).ECT bone scanning showed the improvement rate of bone metastasis was better in A group than B and C group (P ＜ 0.05),and there was no no statistically significant difference between B and C group (P ＞ 0.05).The reducing rate of PSA was not statistically significant in A and C group (P＞ 0.05),while was higher in B group than in A and C group (P ＜0.05).Conclusion Single use of Strontium-89-chloride or medical castration couldn't improve the bone metastasis and the pain of prostate cancer patients with bone metastasis,while combination of the two treatment methods could improve the effect of reducing the pain and control the bone metastasis at the same time.关键词
89SrCl2/药物去势/前列腺癌/骨转移Key words
Strontium-89-chloride/ Medical castration/ Prostate cancer/ Bone metastasis分类
医药卫生引用本文复制引用
刘鹏杰,唐铭,马世兴,朱家伦,刘超,王永斌..内分泌治疗在89SrCl2治疗前列腺癌骨转移中的作用[J].昆明医科大学学报,2013,34(4):122-124,3.
