南京医科大学学报（自然科学版）2013，Vol.33Issue(5)：636-640,5.DOI:10.7655/NYDXBNS20130514
PTEN和P53在非肌层浸润性膀胱肿瘤中的表达及临床意义
Expressions and clinical significances of PTEN and P53 gene in non-muscle-invasive bladder cancer
摘要
Abstract
Objective:To investigate the expression and significance of PTEN and P53 in non-muscle-invasive bladder cancer.Methods:The expression of PTEN and P53 in 121 cases of non-muscle-invasive bladder cancer tissues were determined by the immunochemical SP methods.We combined the clinical follow-up data to analye the relationship between these two markers with tumor stage,grade and recurrence.Results:The expressions of PTEN and P53 protein were detected in 89.2％ and 39.6％ of bladder cancer specimens,respectively.The positive expression rate of PTEN was negatively correlated with the pathological grades and clinical stages of bladder cancer.However,P53 was positively correlated with the pathological grades and clinical stages of bladder cancer.P53 was significantly correlation with the postoperative recurrence.No significant correlation between PTEN in non-muscleinvasive bladder cancer.Conclusion:The detection of the expression of PTEN and P53 in non-muscle-invasive bladder cancer is helpful to estimate the biological behavior and postoperative recurrence.关键词
膀胱肿瘤/PTEN/P53/免疫组化Key words
bladder carcinoma/ PTEN/P53/immunochemistry分类
医药卫生引用本文复制引用
李永飞,唐敏,王尚乾,宋国新,张炜..PTEN和P53在非肌层浸润性膀胱肿瘤中的表达及临床意义[J].南京医科大学学报（自然科学版）,2013,33(5):636-640,5.基金项目
国家自然科学基金(81170612) （81170612）
