青岛大学医学院学报2013，Vol.49Issue(4)：283-285,290,4.DOI:10.11712/qdyxy201304001
子宫内膜癌组织CXCL12及其受体CXCR4mRNA表达及意义
EXPRESSIONS AND CLINICAL SIGNIFICANCE OF CHEMOKINE CXCL12 AND ITS RECEPTOR CXCR4 IN ENDOMETRIAL CARCINOMA
摘要
Abstract
Objective To observe the expressions of chemokine CXCL12 and its receptor CXCR4 in endometrial carcinoma (EC) and their significance.Methods The mRNA expression of CXCL12 and CXCR4 in 12 cases of normal endometrial tissue and 29 of EC tissue were detected by employing RT-PCR.The relationship between the mRNA expressions of CXCL12/CXCR4 and clinicopathologic features of EC was analyzed.Results The mRNA expressions of CXCL12 and CXCR4 in EC tissue were markedly higher than that in normal endometrial tissue (t =3.338,4.174;P ＜0.01),which were positively correlated with each other (r=0.796,P＜0.01).CXCL16 mRNA expression in EC tissue was not associated with clinical stage,pathologic grade,lymph node metastasis,histological type,and patient's age (P ＞0.05).The difference of CXCR4 mRNA expression in differentpathologic-grade EC tissue was significant (F =5.535,P ＜ 0.01),the expression was negatively correlated with the grade (r =-0.472,P＜0.05).CXCR4 mRNA expression was not associated with clinical stage,lymph node metastasis,histological type,and patient's age (P＞0.05).Conclusion In EC tissue,the expressions of CXCL12 and CXCR4 mRNA up-regulate,which prompts that CXCL12 and CXCR4 may play an important role in the development and progression of endometrial carcinoma.关键词
子宫内膜肿瘤/趋化因子,CXCL12/受体,CXCR4Key words
endometrial neoplasms/ chemokines, CXCL12/ receptors, CXCR4分类
医药卫生引用本文复制引用
赵静,宋萌萌,黄煜,崔竹梅,刘相萍..子宫内膜癌组织CXCL12及其受体CXCR4mRNA表达及意义[J].青岛大学医学院学报,2013,49(4):283-285,290,4.基金项目
国家自然科学基金青年基金(30700763)和山东省优秀中青年科学家科研奖励基金(BS2009SW002)资助项目 （30700763）
