现代妇产科进展2013，Vol.22Issue(5)：370-372,3.
孕中期母血清胎盘蛋白13作为预测子痫前期标记物的初步研究
Preliminary study of placental protein 13 as a maternal serum marker for preeclampsia in second-trimester
摘要
Abstract
Objective:To evaluate the value of second-trimester maternal serum placental protein 13(PP13) as a maternal serum marker for preeclampsia prediction.Methods:The maternal serum PP13 concentrations were measured by method of time-resolved fluorescence immunoassay (DEIFIA) in serum samples that were collected from 77 pregnant women with 16,17 and 18 weeks of gestation when they were screened for Down syndrome.55 women with normal pregnancy were classified as control group and 22 women with preeclampsia were recruited as case group.Results:Median PP13 concentration in 16,17 and 18 weeks of gestation were 47.5pmol/L,49pmol/L,51.2pmol/L in control group and 52.7pmoL/L、46.7pmol/L and 42.9 pmol/L in case group respectively.PP13 concentration increased with gestational weeks in control group and decreased in case group(P＜0.05),and there was no significantly difference between the two groups(1.04MOM vs 1.00MOM,P＞0.05).Conclusions:Only PP13 in the serum of pregnant women is not a valuable marker for predicting preeclampsia from 16 to 18 weeks of gestation,but continuous detection of maternal serum PP13 may be useful.关键词
胎盘蛋白13/子痫前期Key words
Placental protein 13/Preeclampsia分类
医药卫生引用本文复制引用
张晓娟,蒋涛,马定远,许争峰..孕中期母血清胎盘蛋白13作为预测子痫前期标记物的初步研究[J].现代妇产科进展,2013,22(5):370-372,3.基金项目
南京医科大学科技发展基金(No:2010NJMU028) （No:2010NJMU028）
江苏省医学领军人才与创新团队(No:LJ201109) （No:LJ201109）
