现代妇产科进展2013，Vol.22Issue(5)：388-392,5.
精子来源对卵胞浆内单精子注射临床结局及子代出生缺陷的影响
Effect of spermatozoa origin on clinical outcome and birth defects after intracytoplasmic sperm injection
董瑞娜 1郭艺红 1苏迎春 1李婧1
作者信息
- 1. 郑州大学第一附属医院生殖医学中心,郑州 450052
- 折叠
摘要
Abstract
Objective:To analyze the clinical outcomes and safety of intracytoplasmic sperm injection(ICSI) using spermatozoa of different sources.Methods:The retrospective study was carried out on 3079 fresh ICSI cycles.According to different sources of spermatozoa,they were divided into three groups:2199 men using ejaculated sperm,628 men with azoospermia underwent percutaneous epididymal aspiration (PESA) and 252 men underwent testicular sperm aspiration (TESA).The embryos development,pregnancy outcomes and birth defects of the three groups were compared.Results:The rate of fertilization was highest in the ejaculated sperm group(78.38％),and lowest in the TESA group(72.30％) (P＜0.05).The rate of 2PN fertilization and cleavage were significantly higher in the ejaculated sperm group and PESA group than in the TESA group (74.68％、75.32％ vs 68.22％,98.82％、98.74％ vs 96.89％).The rate of clinical pregnancy and embryo implantation were significantly higher in the PESA group(53.21％ 、34.31％) than the other two groups(47.11％ 、29.09％ ;48.71％、32.70％) (P＜0.05).The neonatal birth weight was significantly lower in the PESA group than the other two groups(2856.63 ±649.56 vs 2991.73±683.19、2906.11 ±638.76) (P＜0.05).There were no significant differences among three groups in the rate of parturition,ectopic pregnancy,miscarriage,newborns with low birth weight,very low birth weight,macrosomia,neonatal mortality and malformation(P＞0.05).Conclusion:ICSI in combination with PESA and TESA is a safe method.For patients with obstructive azoospermia,the clinical outcome of ICSI using epididymal sperm is better than using testicular sperm when PESA fails.关键词
卵胞浆内单精子注射/经皮附睾穿刺取精术/经皮睾丸精子抽取术/临床结局/出生缺陷Key words
Intracytoplasmic sperm injection/Percutaneous epididymal sperm aspiration/Testicular sperm aspiration/Clinical outcomes/Birth defects分类
医药卫生引用本文复制引用
董瑞娜,郭艺红,苏迎春,李婧..精子来源对卵胞浆内单精子注射临床结局及子代出生缺陷的影响[J].现代妇产科进展,2013,22(5):388-392,5.
