中国实用内科杂志2013，Vol.33Issue(6)：482-484,3.
聚乙二醇化干扰素-α-2a治疗慢性乙型肝炎病毒动力学变化与疗效关系研究
Correlation between the viral dynamics and therapeutic efficacy in chronic hepatitis B patients during therapy with peginterferon alfa-2a
摘要
Abstract
Objective To analyze the correlation between the viral dynamics and therapeutic efficacy in patients with chronic hepatitis B during therapy with peginterferon alfa-2a.Methods Seventy patients with chronic hepatitis B were included and treated with peginterferon alfa-2a for 48 weeks.The serum levels of HBV DNA,HBsAg,HBeAg,HBeAb and ALT were tested at baseline and at 12,24,36,48 weeks during treatment.With these data,the viral dynamic change and its relationship with therapeutic efficacy were analyzed.The significances of the viral dynamics as a predictor of virological response,serological response and biochemical response at the end of treatment were evaluated.Results There were three patterns of HBV dynamics:rapid decline type (16/70,22.9％),slow decline type (35/70,50.0％) and consistent fluctuating type (19/70,27.1％),respectively.The probability of virological response was higher in the rapid and the slow decline type than the consistent fluctuating type.And the probability of complete response was higher in the rapid decline type than the consistent fluctuating type.Conclusion The rapid decline type can be used as a predictor of end-point virological response and complete response.关键词
慢性乙型肝炎/聚乙二醇化干扰素-α-2a/病毒动力学Key words
chronic hepatitis B / peginterferon-alfa-2a/ viral dynamics分类
医药卫生引用本文复制引用
李成伟,赵连荣,丁洋,夏婷婷,王静艳,窦晓光..聚乙二醇化干扰素-α-2a治疗慢性乙型肝炎病毒动力学变化与疗效关系研究[J].中国实用内科杂志,2013,33(6):482-484,3.基金项目
国家"十二五"传染病重大专项课题(2012ZX100002003) （2012ZX100002003）
