国际医药卫生导报2013，Vol.19Issue(16)：2560-2562,3.DOI:10.3760/cma.j.issn.1007-1245.2013.16.044
硫酸镁控制性降压对老年患者髋关节置换术后认知功能和脑氧代谢的影响
Effects of magnesium sulfate on postoperative cognitive dysfunction and cerebral oxygen metabolism during controlled hypotension in elderly patients undergoing hip-replacement
彭惠华 1刘海燕 2樊友凌 1黄芳 1程平瑞 1江伟航1
作者信息
- 1. 511400 广州市番禺区中心医院麻醉科
- 2. 510260 广州,广东省第一荣军医院
- 折叠
摘要
Abstract
Objective To investigated the effects of controlled hypotension on postoperative cognitive dysfunction (POCD) and cerebral oxygen metabolism in elderly patients undergoing hip-replacement.Methods Sixty elderly patients undergoing selective hip-replacement were enrolled in the study.The patients were randomized into two groups with 20 cases in each group.Magnesium sulfate was only administered in group A.Mean arterial pressure (MAP) was reduced by about 30％ and maintained at this level for 30 min.Blood gas analysis was carried out by taking blood samples from right internal jugular vein bulb and radial artery,and arterial to jugular bulb venous oxygen content difference (Da-jvO2) and cerebral oxygen extraction rate (CERO2) were calculated before,during and after controlled hypotension.MMSE was recorded 1 day before and 4 days after operation.Results Compared with group C,MMSE of group A showed no significant change (P ＜ 0.05).The values of Da-jvO2 and CERO2 increased in group A,showing no statistical significant difference.Conclusion Magnesium sulfate induced controlled hypotension in elderly patients undergoing hip-replacement had no effect on POCD.关键词
控制性降压/老年/术后认知功能/脑氧代谢Key words
Controlled hypotension/ Elderly patients/ Postoperative cognitive dysfunction/ Cerebral oxygen metabolism引用本文复制引用
彭惠华,刘海燕,樊友凌,黄芳,程平瑞,江伟航..硫酸镁控制性降压对老年患者髋关节置换术后认知功能和脑氧代谢的影响[J].国际医药卫生导报,2013,19(16):2560-2562,3.
