南京医科大学学报（自然科学版）2013，Vol.33Issue(7)：892-896,5.DOI:10.7655/NYDXBNS20130707
鸡卵清蛋白上游启动子转录因子Ⅱ在人胃癌组织中的表达及临床意义
Expression and clinical significance of chicken ovalbumin upstream promoter transcription factor Ⅱ protein in human gastric carcinoma tissues
摘要
Abstract
Objective:To detect the expression of chicken ovalbumin upstream promoter transcription factor Ⅱ (COUP-TF Ⅱ) protein in human gastric cancer (GC) tissues,and investigate the potential molecular mechanism of COUP-TF Ⅱ involved in the development and advancement of GC and its clinical significance.Methods:Paired tumorous and adjacent non-tumorous human gastric tissues were obtained from 66 patients with GC who underwent surgical resection.The expressions of COUP-TF Ⅱ and MMP-2 protein were detected using immunohistochemistry.The relationship between COUP-TF Ⅱ and the clinicopathologic factors as well as the correlation of COUP-TF Ⅱ and MMP-2 were analyzed.Results:COUP-TF Ⅱ proteins were positively expressed in 65.2％ (43/66) and 19.7％(13/66) of GC tissues and paired non-GC tissues,respectively.The expression of COUP-TF Ⅱ was significandy correlated with the depth of invasion,differentiated grade,lymph node metastasis and tumor-node-metastatsis (TNM) stage (P ＜ 0.05).However,the expression of COUP-TF Ⅱ was not correlated with the gender,age and volume of GC tissues.Patients with positive COUP-TF Ⅱ expression had lower mean survival time than those with negative COUP-TF Ⅱ expression (26.8 ± 2.6 months vs 36.4 ± 3.0 months,x2 =4.118,P =0.042).MMP-2 proteins were positively expressed in 78.8％ (52/66) and 34.8％ (23/66) of GC tissues and paired non-GC tissues,respectively.Moreover,a positive correlation was found between COUP-TF Ⅱ and MMP-2 expression in GC tissues.Conclusion:COUP-TF Ⅱ protein has significant value in determining invasion and metastasis of gastric cancer and assessing prognosis in patients with gastric cancer,and MMP-2 may be involved in the above regulation progress.关键词
胃癌/鸡卵清蛋白上游启动转录因子Ⅱ/基质金属蛋白酶-2/免疫组织化学Key words
gastric cancer/chicken ovalbumin upstream promoter transcription factor Ⅱ (COUP-TF Ⅱ) /MMP-2/immunohistochemistry分类
生物科学引用本文复制引用
李增亮,姜宝飞,李伟,徐皓,徐泽宽..鸡卵清蛋白上游启动子转录因子Ⅱ在人胃癌组织中的表达及临床意义[J].南京医科大学学报（自然科学版）,2013,33(7):892-896,5.基金项目
国家自然科学基金面上项目(81072031) （81072031）
