中国药房2013，Vol.24Issue(28)：2620-2623,4.DOI:10.6039/j.issn.1001-0408.2013.28.10
氟伏沙明对比氯米帕明治疗强迫症的疗效与安全性的Meta分析
Meta-analysis of Efficacy and Safety of Fluvoxamine and Clomipramine in the Treatment of Obsessive-compulsive Disorder
摘要
Abstract
OBJECTIVE:To compare the efficacy and safety of fluvoxamine and clomipramine in the treatment of obsessive-compulsive disorder.METHODS:Retrieved from CNKI,Wanfang database,VIP database,domestic published RCT about fluvoxamine vs.clomipramine in the treatment of obsessive-compulsive disorder were collected,and the methodology of included studies was evaluated.Rev Man 4.2 statistical software was used for Meta-analysis.RESULTS:A total of 11 RCT were included,involving 625 patients.Meta-analysis showed that the total effective rate [OR=1.12,95％CI(0.88,1.55),P=0.51] and cure rate [OR=1.20,95％ CI (0.80,1.80),P=0.38] of fluvoxamine were not statistically significant different from those of clomipramine；the incidence of ADR in fluvoxamine group was significantly lower than in clomipramine group,there was statistical significance (P＜0.05).CONCLUSIONS:Efficacy of fluvoxamine is similar to clomipramine in the treatment of obsessive-compulsive disorder,but shows better safety.关键词
氟伏沙明/氯米帕明/强迫症/Meta分析Key words
Fluvoxamine/ Clomipramine/ Obsessive-compulsive disorder/ Meta-analysis分类
医药卫生引用本文复制引用
何敏,白菁,王艳涛,杨荣梅..氟伏沙明对比氯米帕明治疗强迫症的疗效与安全性的Meta分析[J].中国药房,2013,24(28):2620-2623,4.基金项目
空军后勤部卫生部科研课题(No.BKJ10R019) （No.BKJ10R019）
