摘要
Abstract
OBJECTIVE:To evaluate the clinical efficacy and safety of levocetirizine in the treatment of persistent allergic rhinitis (PAR).METHODS:Retrieved from PubMed,EMbase,Cochrane Library,CNKI,CBM and Wanfang database by compute,randomized controlled trials (RCT) about levocetirizine in the treatment of PAR were included and handsearche was also conducted.The qualities of the included studies were evaluated,and Meta-analysis was conducted by Rev Man 5.0 software.RESULTS:A total of 5 RCTs were included,involving 1 664 patients.Meta-analysis showed that the total symptoms score and health related quality of life score in levocetirizine group were significantly higher than that in control group； there was statistical significance.The overall effective rate [OR=1.10,95％ CI(0.52,2.33),P=0.80],individual nasal symptoms relief and ADR in levocetirizine group were not statistical different from control group [OR=0.63,95％ CI (0.27,1.47),P=0.28].CONCLUSIONS:Levocetirizine could improve the total symptoms of patients with PAR and make the health related quality of life of patients better.But it could not improve the overall effective rate and individual nasal symptoms relief.Moreover,because of less studies of safety about levocetirizine,it still needs further study.关键词
左旋西替利嗪/持续性过敏性鼻炎/Meta分析Key words
Levocetirizine/ Persistent allergic rhinitis/ Meta-analysis分类
医药卫生
