临床肝胆病杂志2013，Vol.29Issue(7)：554-557,4.DOI:10.3969/j.issn.1001-5256.2013.07.021
肝细胞癌中microRNA对细胞凋亡、转移和周期的调控作用
Regulatory effect of miRNAs on apoptosis, migration, and cell cycle of hepatocellular carcinoma cells
许力 1马珂歆 1董兵 1刘海旺 1柳勤龙 1高振明 1孙德光 1张日欣 1王海波1
作者信息
- 1. 大连医科大学附属二院普外科,辽宁大连116027
- 折叠
摘要
Abstract
MicroRNAs (miRNAs) are a class of non-coding single-stranded RNA molecules of about 22 nucleotides in length that are encoded by endogenous gene and participate in post-transcriptional regulation of gene expression.Many evidences indicate that some miRNAs are deregulated in hepatocellular carcinoma (HCC),and it has been found that miRNAs regulate the proliferation,apoptosis,migration,invasion,and cell cycle of HCC cells through some pathways or genes.In addition,some studies suggest that miRNAs function as oncogenes or anti-oncogenes.Therefore,in-depth understanding of the specific role and function of miRNAs in HCC may provide a new approach for the treatment of HCC.关键词
肝肿瘤/微RNAs/细胞凋亡/肿瘤转移/肿瘤侵润/细胞周期Key words
liver neoplasms / microRNAs / apoptosis / neoplasm metastasis / neoplasm invasiveness / cell cycle分类
医药卫生引用本文复制引用
许力,马珂歆,董兵,刘海旺,柳勤龙,高振明,孙德光,张日欣,王海波..肝细胞癌中microRNA对细胞凋亡、转移和周期的调控作用[J].临床肝胆病杂志,2013,29(7):554-557,4.
