临床神经病学杂志2013，Vol.26Issue(1)：9-11,3.
影响高同型半胱氨酸血症型高血压患者血管弹性及内皮功能的相关因素
Correlation factors of arterial stiffness and endothelial function in hypertensive patients with hyperhomocysteinemia
摘要
Abstract
Objective To study the correlation factors of arterial stiffness and endothelial function in hypertensive patients with hyperhomocysteinemia ( HHcy) (H-type hypertensive). Methods According to the serum homocystein (Hcy) levels, 105 essential hypertension patients were divided into H-type hypertension group (66 cases) and hypertension group (39 cases). The arterial stiffness and endothelial function were detected, and the correlation factors of which were analyzed. Results The levels of serum Hey, high-sensitivity C-reactive protein (hs-CRP) , asymmetric dimethylarginine (ADMA) , urinary albumin/creatinine and brachial-ankle pulse wave velocity (baPWV) in H-type hypertension group were significantly higher than those in hypertension group ( P < 0. 05 -0. 01). There were positive correlation between the level of Hcy and age, urinary albumin/creatinine, baPWV, the level of ADMA (P <0. 05-0. 001 ). There were positive correlation between baPWV and age, smoking, diabetes, the levels of hs-CPR, ADMA and Hcy ( P < 0. 05 -0.001). Multiple regression analysis showed that the age, diabetes, levels of Hcy and ADMA were independent correlation with baPWV (all P < 0. 05 ). Conclusion HHcy can aggravate the vascular elasticity reduced and the vascular endothelial function damage in H-type hypertensive patients.关键词
高同型半胱氨酸血症/高血压/同型半胱氨酸/血管弹性/内皮功能Key words
hyperhomocysteinemia/ hypertension/ homocystein/ aortic stiffness/ endothelial function分类
医药卫生引用本文复制引用
夏素琴,吴鑫,王俊宏,李东,周峰..影响高同型半胱氨酸血症型高血压患者血管弹性及内皮功能的相关因素[J].临床神经病学杂志,2013,26(1):9-11,3.基金项目
国家自然科学基金(30900602) （30900602）
