南京医科大学学报（自然科学版）2013，Vol.33Issue(8)：1126-1130,5.DOI:10.7655/NYDXBNS20130819
颅内静脉窦血栓形成的临床分析
Clinical analysis of cerebral venous sinus thrombosis
程虹 1刘圣 2万琪 1葛颂 1张廉 1顾萍 1张磊 1龚洁 1王兴霞1
作者信息
- 1. 南京医科大学第一附属医院神经内科,江苏南京210029
- 2. 南京医科大学第一附属医院放射科,江苏南京210029
- 折叠
摘要
Abstract
Objective:To explore the efficacy and safety of anticoagulant therapy and local thrombolytics in patients with cerebral venous and sinus thrombosis (CVST).Methods:The clinical data of 24 patients with CVST were retrospectively analyzed.These patients were observed after discharge and followed up for 1～3 years.Results:In all the patients included,16 patients only anticoagulated with heparin,8 patients received anticoagulation with heparin and local thrombolytic treatment.At admittion,8 cases showed isolated intracranial hypertension,11 cases with focal deficit,2 cases with encephalopathy and 3 cases with coma.Both the anticoagulation and local thrombolytics were effective.At the end of the follow-up,17 cases (71％) were independent,3 cases (13％) were dependent and 4 cases (17％) died.Concomitant haemorrhageic infarcts related to CVST before treatment were not associated with a poor outcome.Independent predictors of poor outcome were mental disturbance,coma,multiple CVST while predictors of good outcome were thrombosis of single sinus and thrombolytic treatment followed by anticoagulant treatment.Conclusion:In our study,both the heparin therapy and local thrombolysis showed the safety and efficacy in patients with CVST.Local thrombolysis may be a therapeutic option for patients at high risk for a poor outcome despite heparin therapy,possibly in those with intracranial haemorrhages and coma.关键词
颅内静脉窦血栓形成/溶栓治疗/抗凝Key words
cerebral venous and sinus thrombosis /thrombolytics/ anticoagulation分类
医药卫生引用本文复制引用
程虹,刘圣,万琪,葛颂,张廉,顾萍,张磊,龚洁,王兴霞..颅内静脉窦血栓形成的临床分析[J].南京医科大学学报（自然科学版）,2013,33(8):1126-1130,5.
