西北国防医学杂志2013，Vol.34Issue(4)：307-309,3.
K-ras基因突变表达与结直肠癌的相关性分析
Correlation analysis between K-ras gene mutation expression and colorectal cancer
摘要
Abstract
Objective:To investigate the correlation between K-ras gene mutation expression and colorectal cancers.Methods:The specimens from 89 patients with colorectal cancers were collected.K-ras mutations of exon 2 were examined by real-time fluorescence quantitative PCR at codon 12 and codon 13.The results were correspondingly analysed with clinical pathological data.Results:Thirty-seven mutation were found in 89 cases of colorectal cancers.The mutation rate was 41.6％.Twenty-nine mutation occurred in codon 12,and the mutation rate was 32.6％.Eight mutations occurred in codon 13 with 9.0％ mutation rate.No correlation between K-ras mutation and tumor size and differentiation extent was observed.The K-ras mutation rate was related to the infiltrating degree,lymph node metastasis and hepatic metastases.Conclusion:K-ras mutation plays an important role in the carcinogenesis and development of colorectal cancers,which is closely associated with invaded lymph nodes and hepatic metastasis.关键词
结直肠癌/K-ras基因/基因突变Key words
Colorectal cancer/ K-ras gene/ Gene mutation分类
医药卫生引用本文复制引用
宋枫,高峰,杨增强,徐明,赵勇,石磊,吴伟强..K-ras基因突变表达与结直肠癌的相关性分析[J].西北国防医学杂志,2013,34(4):307-309,3.基金项目
兰州军区医药卫生科研计划资助项目(CLZ12JB15) （CLZ12JB15）
