现代妇产科进展2013，Vol.22Issue(6)：477-480,4.
ALX-R在子痫前期患者胎盘组织中的表达及其与NF-κB p65的相关性
Expression of the lipoxin A4 receptor in placenta with preeclampsia and its correlation with nuclear factor-κbp65
摘要
Abstract
Objective:To investigate the expression and its significance of lipoxin A4 receptor and the transcription factor NF-κB p65 in placenta of patients with preeclampsia.Methods:PCR and immunohistochemistry were used to detect the expression of mRNA and protein for ALX-R and NF-KB p65 in the placenta of 30 women with preeclampsia (including 10 cases of mild preeclampsia and 20 cases of severe preeclampsia) and 20 normal full-term pregnant women (control group),respectively.Results:(1) The expression of ALX-R mRNA in placenta was decreased significantly with disease severity,it was lower in severe preeclampsia placenta than in mild preeclampsia and control group (P＜0.01) The expression of NF-KB p65 mRNA in placenta was increased significantly with disease severity,it was higher in severe preeclampsia placenta than in mild preeclampsia and control group(P＜0.05).(2)The expression of ALX-R protein showed significant lower in placenta with preeclampsia than in control group (P＜0.01),and the expression of NF-κB p65 protein showed significant higher in placenta with preeclampsia than in control group(P＜0.01).(3)There was no significant correlated between the expression of ALX-R and NF-κB p65 mRNA and protein in placenta with severe preeclampsia and mild preeclampsia.There was negative correlated between with the expression of ALX-R and NF-κB p65 mRNA and protein in placenta with control group(P＜0.05).Conclusion:The abnormal expressions of ALX-R and NF-κB p65 in placenta may play an important role in the pathogenesis of preeclampsia.关键词
子痫前期/ALX-R/NF-κB p65/RT-PCR/免疫组化Key words
Preeclampsia / Lipoxin A4 receptor/ Nuclear factor-κB p65 / RT-PCR / Immunohistochemistry分类
医药卫生引用本文复制引用
王素梅,唐卉,苏莎,黄玲玲,张晓云..ALX-R在子痫前期患者胎盘组织中的表达及其与NF-κB p65的相关性[J].现代妇产科进展,2013,22(6):477-480,4.基金项目
广西自然科学基金项目(No:2010GXNSFC013015) （No:2010GXNSFC013015）
