同位素稀释-固相萃取-超高效液相色谱-串联质谱技术同时测定畜禽肉中四类兽药残留OA北大核心CSCDCSTPCD
Determination of Four Species of Drugs in Meat by Solid Phase Extraction and UPLC-MS/MS with Isotopes Dilution
建立了畜禽肉中喹诺酮类、磺胺类、硝基咪唑类和青霉素类兽药的同位素稀释-固相萃取-超高效液相色谱-串联质谱分析方法.样品经V(Na2EDTA-Mcllvaine)∶V(乙腈)＝7∶3的混合溶液提取,氮吹后经MCX小柱净化,Waters C18色谱柱分离,以乙腈和0.1％甲酸水溶液为流动相进行梯度洗脱,采用电喷雾-正离子多反应监测模式,内标法定量.在5～200 μg/L质量浓度范围内,4类药物的相关系数均大于0.99,该方法的检出限在0.5～2.0μ…查看全部>>
The four species of drugs residues in meat were determined by solid phase extraction and ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) with isotopes dilution.This method enabled the comprehensive screening for more than 50 drugs including quinolones,sulfonamides,nitroimidazoles and penicillin.The samples were extracted with the mixed solution of Na2EDTA-Mcllvaine and acetonitrile,which volume ratio was 7 ∶ 3,a step for clean-u…查看全部>>
曹慧;陈小珍;朱岩;李祖光;汪丽娜;张晓波
浙江省质量检测科学研究院,浙江杭州310013浙江大学化学系,浙江杭州 310028浙江省质量检测科学研究院,浙江杭州310013浙江大学化学系,浙江杭州 310028浙江工业大学化学工程与材料学院,浙江杭州 310014浙江工业大学化学工程与材料学院,浙江杭州 310014
化学化工
同位素稀释固相萃取超高效液相色谱-串联质谱(UPLC-MS/MS)兽药残留
isotopes dilution solid phase extraction ultra performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS) drugs residues
《质谱学报》 2013 (4)
202-214,13
浙江省科技厅分析测试科技计划项目(2011C37072)浙江省质量技术监督系统科研计划项目(20110203)资助
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