北京大学学报（医学版）2013，Vol.45Issue(3)：359-363,5.DOI:10.3969/j.issn.1671-167X.2013.03.005
PDE4D基因多态性与缺血性卒中的关联性研究
Association study between PDE4D gene polymorphism and ischemic stroke
摘要
Abstract
Objective:To investigate the linkage and association between rs966221 (SNP 83) in PDE4D gene with stroke and related traits in ischemic stroke families.Methods:Ischemic stroke families including ischemic stroke patients and their siblings and/or parents were recruited.Generalized estimating equation (GEE) was used to adjust for with-in family correlations and other potential confounding factors.Non-parameter linkage analysis and family based association test (FBAT) were applied to explore the relationship between rs966221 polymorphism and ischemic stroke together with its related traits.Results:In the study 276 ischemic stroke families with totally 776 participants were enrolled.Apolipoprotein B (apoB),carotid intima media thickness (cIMT),high-density lipoprotein cholesterol and blood pressure were associated with ischemic stroke.In family based association test,after being adjusted for related chronic diseases,rs966221 C allele was found to be associated with cIMT in the dominant model (P =0.019),TT genotype (P =0.019) and CT genotype (P =0.007) were associated with cIMT significantly.After being adjusted for potential confounding factors,evidence of linkage was observed for rs966221 with apoB (P ＜ 0.001),high-sensitivity C-reactive protein (P =0.003) and systolic blood pressure (P =0.036).Conclusion:Abnormal serum lipid,blood pressure and increasing cIMT were associated with ischemic stroke,and linkage was observed for with apoB,high-sensitivity Creactive protein, and systolic blood pressure; rs966221 C allele was probably associated with cIMT.关键词
脑血管意外/环核苷酸磷酸二酯酶类,4型/流行病学,分子/多态现象,单核甘酸Key words
Cerebrovascular accident/ Cyclic nucleotide phosphodiesterases, type 4 / Epidemiology,molecular/ Polymorphism, single nucleotide分类
医药卫生引用本文复制引用
刘括,王晋伟,余治平,秦雪英,武轶群,李娜,隗瑛琦,方凯,王雪茵..PDE4D基因多态性与缺血性卒中的关联性研究[J].北京大学学报（医学版）,2013,45(3):359-363,5.基金项目
国家自然科学基金(81172744,81230066)资助Supported by the National Natural Science Foundation of China(81172744,81230066) （81172744,81230066）
