结直肠肛门外科2013，Vol.19Issue(2)：69-72,4.
腹腔引流液中的细胞因子在早期预测结直肠癌术后肠梗阻中的作用
Cytokines in abdominal exudate to predict postoperative ileus following colorectal carcinoma surgery
摘要
Abstract
Objective To investigate whether measurement of cytokines from abdominal exudate is valuable for an early diagnosis of postoperative ileus (POI) following colorectal surgery.Methods One hundred consecutive patients who were scheduled to undergo elective resection for carcinoma of the sigmoid or rectum were investigated.Abdominal exudate was obtained from a drain tube after surgery for detection of interleukin (IL)-1β,IL-6 and tumour necrosis factor (TNF)-α.The relationship between cytokine levels at postoperative day 1,3 and 5 and the development of POI was investigated.Results Eight patients developed POI,which was diagnosed on postoperative day 10-15.Peritoneal cytokine levels on postoperative days 1 and 3 were not significantly different between the 8 patients who developed POI and 92 patients who did not.In contrast,the cytokine levels on day 5 were significantly higher in patients who developed POI as compared with patients who did not.The cytokines significantly increased during the first 5 days in patients who developed POI,while significantly decreased in patients who did not.Conclusion The results of this investigation showed that the rise in peritoneal IL-1β,IL-6 and TNF-α levels may be an additional early diagnostic predictor of POI following colorectal surgery.关键词
肠梗阻/结直肠癌手术/细胞因子Key words
Postoperative ileus(POI) / Colorectal surgery/ Peritoneal cytokines/ Diagnostic predictor分类
医药卫生引用本文复制引用
朱鹏程,梁中林,崔龙..腹腔引流液中的细胞因子在早期预测结直肠癌术后肠梗阻中的作用[J].结直肠肛门外科,2013,19(2):69-72,4.基金项目
上海市科委基础研究重点项目(10DJ1400504) （10DJ1400504）
