南方医科大学学报2013，Vol.33Issue(7)：972-976,5.DOI:10.3969/j.issn.1673-4254.2013.07.07
Lgr5和CD44在肠息肉和结直肠癌中的表达及意义
Lgr5 and CD44 expressions in different types of intestinal polyps and colorectal cancer
摘要
Abstract
Objective To study the expression of tumorigenesis-related stem cell markers Lgr5 and CD44 in different pathological types of intestinal polyps and their clinical significance in predicting tumorigenesis.Methods A total of 145 cases of colorectal polyps,adenomas and cancer tissues were obtained by colonoscopy biopsy.Immunohistochemistry was employed to detect the expression of Lgr5 and CD44 to analyze their relationship with the occurrence and prognosis of colon and rectal cancer.Results The expression of CD44 in colon cancer tissue was 95.65％,significantly higher than that in normal mucosa (5％),inflammatory hyperplastic polyps (22.58％),tubular adenomatous polyps (55.26％) and villous polyps (75.76％) (P＜0.05).The expression of Lgr5 in colorectal cancer was up to 95.65％ while negative in normal colorectal tissue and was 16.12％ in inflammatory hyperplastic tissues (P＜0.05).The expression rate of Lgr5 was 86.84％ in tubular adenoma and 93.94％ in villous polyps,both comparable with that in colon cancer (P＞0.05).Correlation analysis indicated that the expression of CD44 and Lgr5 were positively correlated with the progression of intestinal polyp tumorigenesis (rs=0.69377,P＜0.0001; rs=0.81637,P＜0.0001).Conclusion Lgr5 and CD44 are highly expressed in colorectal cancer tissues in close correlation with the clinical and pathological features.The expression profiles of Lgr5 and CD44 represent a distinct feature to differentiate colorectal cancer from normal intestinal mucosa.Lgr5 is more closely correlated with tumor progression of polyps than CD44.This means detecting of the expression of Lgr 5 together with CD44 is important and necessary in clinical diagnosis of patients with early stage colorectal diseases such as polyps and their canceration.关键词
肿瘤干细胞/Lgr5/CD44/结肠息肉/结肠癌Key words
cancer stem cells/ Lgr5/ CD44/ colon polyps/ colorectal cancer引用本文复制引用
柴宁莉,张文成,王艳敏,周昭涛,张艳娥,刘红艳,万军,覃金华,王术勇..Lgr5和CD44在肠息肉和结直肠癌中的表达及意义[J].南方医科大学学报,2013,33(7):972-976,5.基金项目
国家自然科学基金(81072913)Supported by National Natural Science Foundation of China (81072913). （81072913）
