南方医科大学学报2013，Vol.33Issue(7)：1087-1090,4.DOI:10.3969/j.issn.1673-4254.2013.07.32
右美托咪定改善成人单肺通气时异丙酚-芬太尼平衡麻醉中的氧合功能
Dexmedetomidine improves oxygenation during one-lung ventilation in balanced anesthesia with propofol-fentanyl in adults
来勇 1李雅兰 1刘育勇 1彭雪梅 1王昊 1邹鹏1
作者信息
- 1. 暨南大学附属第一医院麻醉科,广东广州510630
- 折叠
摘要
Abstract
Objective To investigate the effect of dexmedetomidine on oxygenation function in adult patients with balanced anesthesia by propofol-fentanyl under one-lung ventilation (OLV).Methods Twenty-two patients undergoing thoracic operation were randomly divided into the study group and control group,both receiving propofol and fentanyl balanced anesthesia.In the study group,additional infusion of dexmedetomidine (0.3 μg/kg loading dose,0.3 μg· kg-1· h-1 maintenance dose) was administered,and the patients in the control group received only normal saline.Arterial blood samples were obtained at 4 time points from each patient during anesthesia for blood gas analysis.Results In the study group,the pH values remained stable,the oxygenation index tended to decline progressively, but the incidence of hypoxemia was low; in the control group,the pH value and oxygenation index both declined progressively with a higher incidence of hypoxemia.Conclusion Dexmedetomidine can better maintain the oxygenation function of OLV patients in balanced anesthesia by propofol and fentanyl,and its mechanism may be related to the decreased dose of propofol used.关键词
右美托咪定/单肺通气/氧合/平衡麻醉/异丙酚/芬太尼Key words
dexmedetomidine/ one-lung ventilation/ oxygenation/ balanced anesthesia/ propofol/ fentanyl引用本文复制引用
来勇,李雅兰,刘育勇,彭雪梅,王昊,邹鹏..右美托咪定改善成人单肺通气时异丙酚-芬太尼平衡麻醉中的氧合功能[J].南方医科大学学报,2013,33(7):1087-1090,4.
