南方医科大学学报2013，Vol.33Issue(8)：1107-1110,4.DOI:10.3969/j.issn.1673-4254.2013.08.02
拓扑替康联合环磷酰胺的维持化疗方案可安全和有效治疗完全缓解的晚期神经母细胞瘤
Topotecan plus cyclophosphamide as maintenance chemotherapy for children with high-risk neuroblastoma in complete remission: short-term curative effects and toxicity
摘要
Abstract
Objective To evaluate chemotherapy-related toxicity and the short-term efficacy of topotecan and cydophosphamide as maintenance chemotherapy for stage Ⅳ neuroblastoma in complete remission.Methods The clinical data of 16 children with stage Ⅳ neuroblastoma received 3 cycles of maintenance chemotherapy with topotecan (0.75 mg· m2· day-l,infused on days 0-4) and cyclophosphamide 250 mg· m-2· day-1,infused on days 0-4).The two-year event-free survival after complete remission was recorded and the chemotherapy-related toxicities were evaluated according to the Common Terminology Criteria for Adverse Events of the National Cancer Institute.Results The most common chemotherapy-related toxicity was bone marrow suppression and suppressions of neutrophils,hemoglobin and platelets,which occurred in all the patients mostly of grade Ⅲ and Ⅳ.All the patients experienced episodes of infections,which were controlled effectively with antibiotics.Impairment of gastrointestinal and liver functions in these cases was mostly mild (grade Ⅰ and Ⅱ) and recovered after corresponding treatments.None of the patients exhibited damages in the nervous system or the renal or cardiac functions.After complete remission,the two-year event-free survival rate of these patients was 68.75％ (11/16).Conclusion Topotecan plus cyclophosphamide for maintenance chemotherapy can be effective and relative safe for stage Ⅳ neuroblastoma in complete remission,thus giving a chance to those patients who choose not to have stem cell transplantation.关键词
神经母细胞瘤/化疗/拓扑替康/环磷酰胺Key words
neuroblastoma/chemotherapy/topotecan/cyclophosphamide引用本文复制引用
冯晨,唐锁勤,王建文,刘英,杨光..拓扑替康联合环磷酰胺的维持化疗方案可安全和有效治疗完全缓解的晚期神经母细胞瘤[J].南方医科大学学报,2013,33(8):1107-1110,4.基金项目
Supported by National Natural Science Foundation of China (30772275).国家自然科学基金(30772275) （30772275）
