南方医科大学学报2013，Vol.33Issue(8)：1117-1121,5.DOI:10.3969/j.issn.1673-4254.2013.08.04
海洛因成瘾患者眶额叶皮层功能连接异常与决策能力缺失的关系
Alterations in orbitofrontal cortex functional connectivity and decision making deficits in heroin-dependent individuals
摘要
Abstract
Objective To investigate the changes in orbitofrontal cortex (OFC) functional connectivity and its association with decision-making deficits in chronic heroin-dependent individuals (HDIs) and explore the neural mechanisms of heroin addiction and relapse.Methods Fourteen male chronic HDIs and 14 healthy subjects matched for age,education,and nicotine consumption participated in this study.Resting state functional magnetic resonance imaging (fMRI) was performed using a 1.5 T MR scanner.Functional connectivity of the OFC and the rest of the brain were calculated using REST software.Voxel-based analysis of the functional connectivity maps between the control and HDI groups was performed with two-sample t test.The Iowa gambling task (IGT) was used to assess the participants' decision making during uncertainty.Results Compared with the control group,the HDIs showed significantly decreased functional connectivity of the OFC and the right inferior parietal lobule (rIPL) (t=3.5,P＜0.05).A significant negative correlation was noted between the functional connectivity of the OFC-rIPL and performance level at the IGT.Conclusion The OFC-rIPL functional connectivity is significantly disrupted in HDIs,which may be the neural basis for decision-making deficits.关键词
海洛因/成瘾/功能磁共振/功能连接/决策能力缺失/眶额叶皮层Key words
heroin, addiction/functional MRI/functional connectivity/decision-making deficit/orbitofrontal cortex引用本文复制引用
邱迎伟,江桂华,苏欢欢,马晓芬,李黎明,田军章,张雪林..海洛因成瘾患者眶额叶皮层功能连接异常与决策能力缺失的关系[J].南方医科大学学报,2013,33(8):1117-1121,5.基金项目
国家自然科学基金(81201084) （81201084）
广东省科技计划项目(2011B031800044)Supported by National Natural Science Foundation of China (81201084). （2011B031800044）
