南方医科大学学报2013，Vol.33Issue(8)：1189-1193,5.DOI:10.3969/j.issn.1673-4254.2013.08.20
基质金属蛋白酶-9在后交通动脉瘤瘤周蛛网膜中的表达及临床意义
Expression of matrix metalloproteinase-9 in the arachnoid membrane around posterior communicating artery aneurysms
摘要
Abstract
Objective To investigate the expression of matrix metalloproteinase-9 (MMP-9) in the arachnoid membrane around posterior communicating artery aneurysms.Methods Twelve patients with posterior communicating artery aneurysms undergoing surgical intervention in our hospital between November,2010 and November,2011 were enrolled as the case group along with 6 concurrent patients with severely head trauma or epilepsy as controls.The expression of MMP-9 in the aneurysmal walls and the arachnoid membrane was examined in immunohistochemistry,and HE staining and Sirus red staining were performed to examine the pathological changes.Results The perianeurysmal arachnoid membrane showed tissue destruction and disruption of the connections between the membrane and the artery wall with local detachment.Compared with that in the control group,the level of MMP-9 in the arachnoid membrane was significantly higher in the case group (P＜0.05),but significantly lower than that in the aneurysm wall within the same sample (P＜0.05).No differences were found in the levels of MMP-9 in the aneurysm patients with different ages or Hunt-Hess scale scores.Conclusion MMP-9 is closely related with the formation of posterior communicating artery aneurysms by causing degradation of extracellular matrix of the vascular wall and the arachnoid membrane.关键词
基质金属蛋白酶-9/后交通动脉瘤/蛛网膜Key words
matrix metalloproteinase-9/posterior communicating artery aneurysms/arachnoid membrane引用本文复制引用
冯文峰,王刚,张国忠,李伟光,李明洲,何小艳,张龙,漆松涛..基质金属蛋白酶-9在后交通动脉瘤瘤周蛛网膜中的表达及临床意义[J].南方医科大学学报,2013,33(8):1189-1193,5.基金项目
广东省自然科学基金(S2011010003898) （S2011010003898）
南方医科大学南方医院院长基金(2010B020) （2010B020）
