南方医科大学学报2013，Vol.33Issue(8)：1213-1216,4.DOI:10.3969/j.issn.1673-4254.2013.08.25
自发性蛛网膜下腔出血患者CD4+CD25+调节性T细胞变化特点与意义
Changes in CD4 + CD25 + regulatory T cells in patients with spontaneous subarachnoid hemorrhage
摘要
Abstract
Objective To explore the role of CD4+CD25+ regulatory T cells (Treg) in the occurrecne of spontaneous subarachnoid hemorrhage (SAH).Methods Fifteen patients with spontaneous SAH,15 with traumatic SAH,and 15 with headache without organic pathologies as confirmed by lumbar puncture (control group) were examined with flow cytometry for Treg in the peripheral blood and cerebrospinal fluid and intracellular cytokine interleukin-10 (IL-10) and transforming growth factor beta1 (TGF-β1) levels.The Glasgow score (GCS),neurological deficit score (NIHSS),headache,visual analog scale (VAS) and hospitalization time were compared between the two SAH groups.Results Spontaneous SAH patients showed significantly lowered peripheral blood Treg,IL-10,and TGF-β1 in the cerebrospinal fluid compared with the patients with traumatic SAH and the control group (P＜0.05),and the 3 measurements were comparable between the latter two groups (P＞0.05).After administration of treatment,of Treg content in spontaneous SAH patients increased progressively and became comparable with those in the other two groups at the third and fourth lumbar punctures.Spontaneous SAH patients showed significantly lower GCS,NIHSS,and VAS with shorter hospital stay than the traumatic SAH patients.Correlation analysis showed that Treg,IL-10 and TGF-β1 were all inversely correlated with NIHSS,VAS,and duration of hospitalization but positively correlated with GCS (the absolute r values were all greater than 0.6,P＜0.05).Conclusion Treg deficiency can be an important mechanism for the occurrence of spontaneous SAH,and a higher level of Treg indicates a better outcome of the patients.关键词
蛛网膜下腔出血/动脉瘤/免疫/CD4+CD25调节性T细胞Key words
subarachnoid hemorrhage/aneurysm/immune/CD4+CD25+ regulatory T cells引用本文复制引用
梁仔,罗赛华..自发性蛛网膜下腔出血患者CD4+CD25+调节性T细胞变化特点与意义[J].南方医科大学学报,2013,33(8):1213-1216,4.基金项目
广东省科技计划项目(2011B031800048) （2011B031800048）
