辐射防护2013，Vol.33Issue(4)：193-198,248,7.
自吞噬促进电离辐射之后细胞的存活
Autophagy Promotes Cell Survival after Gamma Irradiation
摘要
Abstract
p53 kockdown and control cells were constructed through lentiviral.Inducing and inhibiting autophagy by serum starvation and 3-MA respectively,and then irradiated cells with γ-ray.Results proves that p53 represses the expression of the autophogy effector-p62/SQSTM1,which possibly explains the new mechanism of p53 inhibition on autophagy.Meanwhile,the induction of autophagy before and after irradiation is demonstrated to be promoting cell survival,which highlights the importance of autophagy in determining the cell fate after irradiation.Further investigation revealed that autophagy inhibition strongly suppresses DNA damage induced cell cycle G2/M arrest which provides new clue to explain the relationship between cell cycle arrest and cell survival.关键词
电离辐射/自吞噬/细胞周期阻滞/细胞凋亡Key words
ionizing radiation/ autophagy/ cell cycle arrest/ apoptosis分类
生物科学引用本文复制引用
李俊英,杨艳丽,张赫,刘晓丹,张士猛,周平坤..自吞噬促进电离辐射之后细胞的存活[J].辐射防护,2013,33(4):193-198,248,7.基金项目
国家自然科学基金资助项目(编号:81071361,81272998). （编号:81071361,81272998）
