广东医学2013，Vol.34Issue(14)：2153-2155,3.
广东省HIV/HCV共感染者及单纯HIV感染者HIV-1基因亚型分析
Human immunodeficiency virus type 1 (HIV-1) subtypes in HIV/HCV co-infected and HIV-1 mono-infected individuals in Guangdong Province
摘要
Abstract
Objective To investigate the transmission routes and subtypes distribution of HIV in HIV/HCV co-infected and HIV mono-infected individuals in Guangdong Province.Methods Reverse transcription nested (RT-PCR) was performed to amplify the HIV-1 ENV c2v3 and GAG p17 gene regions from 51 HIV/HCV co-infected and 48HIV mono-infected individuals in Guangdong province.The PCR products were sequenced for HIV subtyping.Genetic analysis was done by MEGA4 software.Results Injection drug use (IDU,82％) was the main route of the transmission of HIV/HCV co-infection.The HIV subtype CRF01_AE (54.9％),CRF07_BC (33.3％),CRF08_BC (4％) and B'(7.8％) were identified; among which CRFO1 AE (54.7％) was proved the predominant one in HIV/HCV co-infection through IDU.The sexual contact (77％) was the main route of the transmission of HIV mono-infection.The HIV subtype CRF01_AE (77.1％),CRF07_BC (10.4％),CRF08_BC (6.2％),B' (4.2％) and B (2.1％) were identified; among which CRF01_AE (78.4％) was proved the predominant one in HIV mono-infection through sexual contact.Conclusion Sufficient diversity of HIV subtype in HIV/HCV co-infection or HIV mono-infection in Guangdong province is revealed.Although the major transmission routes of HIV/HCV co-infection and HIV mono-infection are differed,the major HIV subtype is identical.关键词
人免疫缺陷病毒1型/丙型肝炎病毒/共感染/基因亚型Key words
human immunodeficiency virus type 1 / hepatitis C virus/ co-infection/ subtype引用本文复制引用
袁小珍,陈伟烈,卓丽..广东省HIV/HCV共感染者及单纯HIV感染者HIV-1基因亚型分析[J].广东医学,2013,34(14):2153-2155,3.基金项目
广州市医药卫生科技重点项目(编号:2007-ZDi-03) （编号:2007-ZDi-03）
