广东药学院学报2013，Vol.29Issue(3)：229-232,4.DOI:10.3969/j.issn.1006-8783.2013.03.002
N-三甲基壳聚糖对青藤碱脂质体体外性质的影响
Effect of N-trimethyl chitosan on in vitro properties of sinomenine hydrochloride liposomes
陈康 1何文 2张先洲2
作者信息
- 1. 湖北省妇幼保健院药剂科,湖北武汉430070
- 2. 武汉大学人民医院药学部,湖北武汉430060
- 折叠
摘要
Abstract
Objective To study the effect of N-trimethyl chitosan (TMC)on the in vitro sinomenine hydrochloride (SH) liposomes (SHL).Methods SHL was prepared by ether injection method followed by TMC coating with various degrees of quaternization (DQ of 20％,40％ and 60％).The morphology,size,Zeta potential,entrapment efficiency and transdermal penetration in vitro of the TMC-coated SHL were studied and compared with those of un-coated SHL.Results Compared with those of un-coated SHL,the size and Zeta potential of TMC-coated SHL were both increased with the increase of DQ.At the beginning of in vitro transdermal penetration,TMC-coated SHL showed notable lag time which was decreased with the increase of DQ.After the lag time,the transdermal penetration rate was enhanced significantly and depended on the increase of DQ.TMC-coating had no significant effect on the entrapment efficiency of SHL.Conclusion After coated by TMC,such in vitro properties of SHL as size,Zeta potential and transdermal penetration showed relative changes,which depended on the DQ of TMC.关键词
N-三甲基壳聚糖/青藤碱/脂质体/体外性质Key words
N-trimethyl chitosan/ sinomenine hydrochloride / liposomes / in vitro properties分类
药学引用本文复制引用
陈康,何文,张先洲..N-三甲基壳聚糖对青藤碱脂质体体外性质的影响[J].广东药学院学报,2013,29(3):229-232,4.
