广东药学院学报2013，Vol.29Issue(3)：233-236,4.DOI:10.3969/j.issn.1006-8783.2013.03.003
磷酸川芎嗪缓释滴丸在兔体内的药动学和相对生物利用度研究
Study on the pharmacokinetics and relative bioavailability of tetramethylpyrazine phosphate sustained-release dropping pills in rabbits
吴声振 1雷凯君 1霍钻云1
作者信息
- 1. 佛山市中医院药剂科,广东佛山528000
- 折叠
摘要
Abstract
Objective To study the pharmacokinetics and relative bioavailability of tetramethylpyrazine phosphate(TMPP) sustained-release dropping pills and MPP conventional tablets in rabbits.Methods Single dose of 150 mg TMPP sustained-release dropping pills or conventional tablets were orally given to 12 rabbits in a randomized crossover study.The TMPP concentration in plasma was determined by high performance liquid chromatography,and the pharmacokinetic parameters and relative bioavailability were calculated by DAS 2.1 software.Results The main pharmacokinetic parameters for TMPP sustained-release dropping pills and conventional tablets were as follows:tmax (4.17 ± 0.41) h and (1.08 ± 0.49) h ; Cmax (3.240±0.471) mg · L-1 and(6.125 ±0.298) mg· L-1 ;AUC0-∞ (38.549 ±2.408) mg · L-1 · h and (33.067 ± 2.214) mg · L-1 · h ; The relative bioavailability of TMPP sustained-release dropping pills to conventional tablets was (116.58 ± 10.24) ％.Conclusion The pharmacokinetics of TMPP in rabbits was in accord with the two compartment models and with the first absorption after TMPP sustained-release dropping pills or conventional tablets administration.AUC0-∞ and tmax of TMPP sustained-release dropping pills were all higher than those of conventional tablets,and TMPP sustained-release dropping pills had a higher bioavailability.关键词
磷酸川芎嗪/缓释/滴丸/药动学/相对生物利用度Key words
tetramethylpyrazine phosphate/ sustained-release/ dropping pills/ pharmacokinetics / relative bioavailability分类
药学引用本文复制引用
吴声振,雷凯君,霍钻云..磷酸川芎嗪缓释滴丸在兔体内的药动学和相对生物利用度研究[J].广东药学院学报,2013,29(3):233-236,4.
