广东药学院学报2013，Vol.29Issue(3)：240-245,6.DOI:10.3969/j.issn.1006-8783.2013.03.005
NCP4及其结构类似物9-硝基喜树碱和10-羟基喜树碱的质谱裂解规律研究
Study on the mass fragmentation pathway of NCP4,9-nitrocamptothecin and 10-hytroxycamptothecin
摘要
Abstract
Objective To study the fragmentation pathway of NCP4,9-nitrocamptothecin and 10-hytroxycamptothecin.Methods In positive and negative modes,NCP4,9-nitrocamptothecin and 10-hytroxycamptothecin were identified by ESI-MSn.Their fragmentation pathways were explained with the aid of frontier 6.0 program.The comparison of the fragmentation mechanism of NCP4,9-nitrocamptothecin and l 0-hytmxycamptothecin were made.Results In positive mode,ion peaks m/z 516 [M + Na] +,472,416,350 were detected for NCP4,m/z 394 [M + H] +,365,350,304 for 9-nitrocamptothecin,m/z 365 [M + H] +,321,293,265 for 10-hytroxycamptothecin.In negative mode,ion peaks m/z 448,419,391,330 were detected for NCP4.m/z 392 [M-H],348,304 for 9-nitrocamptothecin,m/z 363 [M-H]-,319,291 for 10-hytroxycamptothecin.Conclusion NCP4 was cracked by losing-NO2,-CO2 and-C4H8,and 9-nitrocamptothecin and 10-hytroxycamptothecin were cracked by losing-CO2.关键词
NCP4/9-硝基喜树碱/10-羟基喜树碱/质谱分析/裂解规律Key words
NCP4 / 9-nitrocamptothecin/ 10-hytroxycamptothecin/ mass spectrometry / fragmentation pathway分类
医药卫生引用本文复制引用
李文学,何菁宇,曹娣,宋粉云,范国荣..NCP4及其结构类似物9-硝基喜树碱和10-羟基喜树碱的质谱裂解规律研究[J].广东药学院学报,2013,29(3):240-245,6.基金项目
科技部"重大新药创制"科技重大专项(2009ZX09103-123,2012ZX09102101-005) （2009ZX09103-123,2012ZX09102101-005）
