广东药学院学报2013，Vol.29Issue(3)：295-297,3.DOI:10.3969/j.issn.1006-8783.2013.03.019
羊藿巴戟口服液对去势大鼠雌二醇的影响及机制
Effect of Yanghuobaji oral liquid on estradiol level in ovariectomized rats
潘雪刁 1蔡帆 1徐铮弟 2张海涛 1臧林泉 1张建华1
作者信息
- 1. 广东药学院,广东广州510006
- 2. 广州市万正药业有限公司,广东广州510663
- 折叠
摘要
Abstract
Objective To investigate the effect of Yanghuobaji oral liquid (YHBJ) on estradiol level and kidneyand-yin replenishing in ovariectomized rats.Methods 48 female SD rats were sham-operated or ovariectomized,and randomly divided into 6 groups including the sham-operated group,the model control group,the diethylstilbestrol group (2.25 × 10-5 g· kg-1) and three YHBJ groups with low (1.0 g · kg-1),middle (3.0 g· kg-1) and high (6.0 g · kg-1) doses.After treatment for 15 days,the level of serum estradiol was detected by high performance liquid chromatography (HPLC).The organ index of adrenal and uterus were also detected.Results Compared with model control group,YHBJ treatment increased the organ index of adrenal and uterus in ovariectomized rats in a dose-dependent manner (P ＜ 0.05,P ＜ 0.01).The serum estradiol level in the high-dose YHBJ group was significantly higher than those of the model control group (P ＜ 0.05).Conclusion YHBJ may contribute to the effect of kidney-and-yin replenishing.关键词
淫羊藿/巴戟天/雌二醇/去势大鼠Key words
herba epimedii / morinda officinalis / estradiol/ ovariectomized rat分类
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潘雪刁,蔡帆,徐铮弟,张海涛,臧林泉,张建华..羊藿巴戟口服液对去势大鼠雌二醇的影响及机制[J].广东药学院学报,2013,29(3):295-297,3.
