广东药学院学报2013，Vol.29Issue(3)：305-309,5.DOI:10.3969/j.issn.1006-8783.2013.03.022
紫檀芪对白色念珠菌生物膜的体外抑制作用
The inhibitory activity of pterostilbene on Candida albicans biofilms
钟罗枫 1王文丽 1陈慧芝 1彭苑霞 1徐晖 1詹若挺 1陈蔚文1
作者信息
- 1. 广州中医药大学中药资源科学与工程研究中心/岭南中药资源教育部重点实验室,广东广州510006
- 折叠
摘要
Abstract
Objective To study the in vitro inhibitory activity of pterostilbene on C.albicans biofilms.Methods The effect of pterostilbene on the formation of C.albicans biofilms was measured by XTT-reduction assay.The susceptibility to pterostilbene at different stages of biofilm progression was examined.The morphological changes of C.albicans biofilms exposed to pterostilbene were observed by inverted microscopy.Results Pterostilbene apparently inhibited C.albicans biofilm formation and filamentation in a concentration-dependent manner,in which the inhibition ratio was over 90％ at the dosage of 0.211 or 0.422 mmol · L-1.The susceptibility to pterostilbene at different stages of biofilm progression was varied.The inhibition ratio in all stages was over 80％ at the dosage of 0.211 or 0.422 mmol · L-1 pterostilbene,while the lower concentration of pterostilbene at 0.0026,0.053 or 0.106 mmol · L-1 showed stronger inhibitory effect on the mature stage than the early stage of biofilm progression.Conclusion Pterostilbene exhibits a potent inhibitory activity against C.albicans biofilm formation.关键词
紫檀芪/白色念珠菌/生物膜/体外抑制作用Key words
pterostilbene/ Candida albicans / biofilm/ in vitro inhibitory activity分类
医药卫生引用本文复制引用
钟罗枫,王文丽,陈慧芝,彭苑霞,徐晖,詹若挺,陈蔚文..紫檀芪对白色念珠菌生物膜的体外抑制作用[J].广东药学院学报,2013,29(3):305-309,5.
