国际神经病学神经外科学杂志2013，Vol.40Issue(3)：216-219,4.
帕金森病认知障碍与血尿酸水平的相关性分析
Association between serum uric acid level and cognitive impairment in patients with Parkinson's disease
摘要
Abstract
Objective To measure the serum uric acid concentration in patients with Parkinson' s disease (PD) and examine the relationship between serum uric acid level and cognitive impairment in PD patients.Methods Eighty-seven PD patients and 81 control subjects were recruited.Their cognitive functions were evaluated using the Mini-Mental State Examination,Wechsler Intelligence Scale,and Wechsler Memory Scale ; the motor aspects of the disease were assessed using section Ⅲ of the Unified Parkinson Disease Rating Scale,and the severity of the disease was determined using the Hoehn-Yahr (H-Y) scale.Serum uric acid concentration was measured and then was compared between PD patients and controls and between the patients with different H-Y stages of PD.Linear regression analysis was employed to analyze the correlation between serum uric acid level and neuropsychological performance.Results Serum uric acid level was significantly lower in the PD patients than in the controls (P ＜ 0.05).There was no significant difference in serum uric acid level between patients with H-Y stage ＜3 PD and those with H-Y stage≥3 PD (P ＞0.05).The multipie linear regression analysis revealed no correlation between serum uric acid level and neuropsychological performance (P ＞ 0.05).Conclusions Decrease in serum uric acid level may be associated with PD,but it may not be associated with cognitive impairment in PD patients.关键词
帕金森病/认知功能/尿酸/氧化应激/生物标记/发病机制Key words
Parkinson's disease/cognitive function/uric acid/oxidative stress/biological marker/pathogenesis引用本文复制引用
张玉虎,甘蓉,聂坤,王丽敏,赵洁皓,黄智恒,张雄,万鑫,王丽娟..帕金森病认知障碍与血尿酸水平的相关性分析[J].国际神经病学神经外科学杂志,2013,40(3):216-219,4.基金项目
国家自然科学基金(30801219 （）
30870863) （）
广东省科技计划项目(2011B080701087) （2011B080701087）
